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QuickView for COMT (gene)


Gene Symbol:
COMT Homo sapiens Homo sapiens
Full name:
catechol-O-methyltransferase
Synonyms:
HEL-S-98n, catechol O-methyltransferase, catechol-O-methyltransferase isoform, epididymis secretory sperm binding protein Li 98n, testicular tissue protein Li 42
Genomic Location:
Chr 22: 18309309-18336530
Description:
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous s...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Canis lupus familiaris Pan troglodytes Danio rerio Bos taurus
External Links:
Entrez Gene
Cytogenetic Map:
chr 22
22q11.21





GO Molecular Function

catechol O-methyltransferase activity | cation binding | magnesium ion binding | S-adenosylmethionine-dependent methyltransferase activity | L-dopa O-methyltransferase activity | catalytic activity | O-methyltransferase activity | ion binding | protein binding | transferase activity | methyltransferase activity | metal ion binding | orcinol O-methyltransferase activity

GO Biological Process

response to extracellular stimulus | response to nutrient levels | response to lipopolysaccharide | regulation of localization | catechol-containing compound metabolic process | negative regulation of cellular process | cellular response to extracellular stimulus | response to drug | estrogen metabolic process | regulation of renal sodium excretion | catechol O-methyltransferase activity | phenol-containing compound metabolic process | cellular process | organic substance catabolic process | female pregnancy | multicellular organismal reproductive process | learning | catecholamine catabolic process | negative regulation of secretion | cellular response to starvation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of neurological system process | regulation of cellular process | regulation of metabolic process | catabolic process | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | regulation of sulfur amino acid metabolic process | response to pain | regulation of excretion | response to stress | regulation of cell proliferation | response to starvation | reproduction | L-dopa O-methyltransferase activity | response to molecule of bacterial origin | regulation of dopamine metabolic process | negative regulation of transport | negative regulation of metabolic process | dopamine metabolic process | drug catabolic process | regulation of catecholamine metabolic process | regulation of neurotransmitter levels | organic hydroxy compound metabolic process | response to external biotic stimulus | cellular response to nutrient levels | nitrogen compound metabolic process | reproductive process | O-methyltransferase activity | learning or memory | lipid metabolic process | regulation of hormone levels | regulation of sensory perception of pain | dopamine catabolic process | methylation | regulation of cellular amino acid metabolic process | cellular response to stress | response to lipid | nervous system process | positive regulation of cellular metabolic process | negative regulation of smooth muscle cell proliferation | regulation of nitrogen compound metabolic process | cognition | neurotransmitter metabolic process | cellular response to phosphate starvation | neurotransmitter catabolic process | response to bacterium | response to estrogen | cell communication | regulation of cellular metabolic process | regulation of homocysteine metabolic process | short-term memory | aromatic compound catabolic process | positive regulation of homocysteine metabolic process | drug metabolic process | multicellular organism reproduction | multicellular organismal response to stress | response to organic substance | catecholamine metabolic process | negative regulation of dopamine metabolic process | metabolic process | regulation of secretion | behavior | organic substance metabolic process | memory | organonitrogen compound catabolic process | steroid metabolic process | response to organic cyclic compound | hormone metabolic process | response to biotic stimulus | regulation of cellular ketone metabolic process | methyltransferase activity | developmental process | regulation of transport | negative regulation of cell proliferation | positive regulation of metabolic process | cellular metabolic process | negative regulation of renal sodium excretion | regulation of smooth muscle cell proliferation | orcinol O-methyltransferase activity | response to other organism | multicellular organismal process

GO Cellular Component

dendritic spine | integral component of membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cell body | cell | intrinsic component of membrane | synaptic membrane | cytoplasm | intracellular organelle | dendritic tree | cell projection | postsynaptic membrane | neuron spine | postsynapse | plasma membrane | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | axon | cytosol | intracellular | membrane