QuickView for CP8B (gene)
- Gene Symbol:
- CYP8B1
Homo sapiens - Full name:
- cytochrome P450 family 8 subfamily B member 1
- Synonyms:
- CP8B, CYP12, 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase, 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase, CYPVIIIB1, cytochrome P450 8B1, cytochrome P450, family 8, subfamily B, polypeptide 1, cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1, sterol 12-alpha-hydroxylase
- Genomic Location:
- Chr 3: 42888688-42892637
- Description:
-
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
3p22.1
GO Molecular Function
cofactor binding | cation binding | steroid hydroxylase activity | iron ion binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity | ion binding | organic cyclic compound binding | tetrapyrrole binding | oxygen binding | sterol 12-alpha-hydroxylase activity | transition metal ion binding | heme binding | drug binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
bile acid biosynthetic process | sterol metabolic process | cellular process | steroid hydroxylase activity | organic cyclic compound metabolic process | steroid biosynthetic process | monocarboxylic acid metabolic process | cellular biosynthetic process | organic hydroxy compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity | small molecule metabolic process | biosynthetic process | lipid biosynthetic process | carboxylic acid metabolic process | bile acid metabolic process | sterol 12-alpha-hydroxylase activity | metabolic process | oxidation-reduction process | organic substance metabolic process | steroid metabolic process | organic acid metabolic process | cellular metabolic process | oxidoreductase activity
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane
