QuickView for CPAP (gene)

Gene Symbol:

CENPJ Homo sapiens

Full name:

centromere protein J

Synonyms:

BM032, CENP-J, CPAP, LAP, LIP1, MCPH6, SASS4, SCKL4, Sas-4, centromere protein J, LAG-3-associated protein, LYST-interacting protein 1, LYST-interacting protein LIP1, LYST-interacting protein LIP7, centrosomal P4.1-associated protein

Genomic Location:

Chr 13: 24354412-24395085

Description:

This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signa...

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This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATCATGA_MIR433

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-433-3p

miRNA binding sites
(Source: miRecords):

hsa-miR-15a/hsa-miR-16 Targeted Genes

Cytogenetic Map:

13q12.12-q12.13

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