QuickView for CPSF30 (gene)

Gene Symbol:

CPSF4 Homo sapiens

Full name:

cleavage and polyadenylation specific factor 4

Synonyms:

CPSF30, NAR, NEB-1, NEB1, cleavage and polyadenylation specificity factor subunit 4, CPSF 30 kDa subunit, NS1 effector domain-binding protein 1, cleavage and polyadenylation specific factor 4, 30kDa, cleavage and polyadenylation specificity factor 30 kDa subunit, no arches homolog, no arches-like zinc finger protein

Genomic Location:

Chr 7: 98874499-98892932

Description:

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In ...

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Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  AP2_Q6_01 ,  AP2_Q3 ,  AATGTGA_MIR23A_MIR23B ,  CCTGCTG_MIR214 ,  RCGCANGCGY_NRF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-323

Cytogenetic Map:

7q22.1

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