QuickView for CPSF73 (gene)
- Gene Symbol:
- CPSF3
Homo sapiens - Full name:
- cleavage and polyadenylation specific factor 3
- Synonyms:
- CPSF-73, CPSF73, cleavage and polyadenylation specificity factor subunit 3, cleavage and polyadenylation specific factor 3, 73kDa, mRNA 3'-end-processing endonuclease CPSF-73
- Genomic Location:
- Chr 2: 9481319-9530678
- Description:
-
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRN...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
2p25.1
GO Molecular Function
nuclease activity | cation binding | nucleic acid binding | hydrolase activity | ribonuclease activity | catalytic activity | hydrolase activity, acting on ester bonds | ion binding | organic cyclic compound binding | protein binding | endoribonuclease activity | endonuclease activity | exonuclease activity | metal ion binding | heterocyclic compound binding | 5'-3' exonuclease activity | RNA binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | RNA processing | nuclear export | mRNA cleavage | nuclease activity | establishment of localization | intracellular transport | cellular process | localization | protein transport | macromolecule localization | establishment of localization in cell | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | protein export from nucleus | RNA splicing | histone mRNA metabolic process | intracellular protein transport | RNA splicing, via transesterification reactions | cellular nitrogen compound biosynthetic process | snoRNA metabolic process | ncRNA 3'-end processing | ncRNA processing | cellular localization | cellular nitrogen compound metabolic process | termination of RNA polymerase II transcription | nucleic acid phosphodiester bond hydrolysis | mRNA metabolic process | ribonuclease activity | cellular biosynthetic process | mRNA polyadenylation | mRNA export from nucleus | RNA polyadenylation | snoRNA 3'-end processing | nitrogen compound metabolic process | ribonucleoprotein complex localization | organic substance transport | peptide transport | biosynthetic process | aromatic compound biosynthetic process | RNA export from nucleus | mRNA transport | establishment of RNA localization | protein-containing complex localization | DNA-templated transcription, termination | snoRNA splicing | endoribonuclease activity | nucleobase-containing compound transport | metabolic process | RNA phosphodiester bond hydrolysis, endonucleolytic | RNA 3'-end processing | cellular protein localization | amide transport | nucleobase-containing compound metabolic process | organic substance metabolic process | nuclear transport | RNA phosphodiester bond hydrolysis | gene expression | endonuclease activity | establishment of protein localization | transcription, DNA-templated | RNA transport | protein localization | cellular macromolecule localization | cellular macromolecule biosynthetic process | nucleocytoplasmic transport | mRNA 3'-end processing by stem-loop binding and cleavage | exonuclease activity | ncRNA metabolic process | heterocycle metabolic process | snoRNA processing | 5'-3' exonuclease activity | mRNA 3'-end processing | cellular metabolic process | pre-mRNA cleavage required for polyadenylation | mRNA processing | RNA localization | mRNA splicing, via spliceosome | mRNA cleavage involved in mRNA processing | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | mRNA cleavage factor complex | cell | nuclear lumen | intracellular organelle | protein-containing complex | nucleoplasm | mRNA cleavage and polyadenylation specificity factor complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
