QuickView for CRCR1 (gene)

Gene Symbol:

DCC Homo sapiens

Full name:

DCC netrin 1 receptor

Synonyms:

CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1, netrin receptor DCC, colorectal cancer suppressor, deleted in colorectal carcinoma, immunoglobulin superfamily DCC subclass member 1, putative colorectal tumor suppressor, tumor suppressor protein DCC

Genomic Location:

Chr 18: 48120569-49311780

Description:

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate...

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This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTACAGG_MIR486

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-486

Cytogenetic Map:

18q21.2

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