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QuickView for CRDGF (gene)


Gene Symbol:
AREG Homo sapiens Homo sapiens
Full name:
amphiregulin
Synonyms:
AR, AREGB, CRDGF, SDGF, amphiregulin, amphiregulin B, colorectum cell-derived growth factor, schwannoma-derived growth factor
Genomic Location:
Chr 4: 75529717-75539590
Description:
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 4
4q13.3


Transcripts Names
NM_001657
Protein Names
Q5U026
P15514



GO Molecular Function

signaling receptor binding | molecular function regulator | protein binding | receptor regulator activity | growth factor activity | receptor ligand activity | cytokine activity | epidermal growth factor receptor binding | growth factor receptor binding

GO Biological Process

glial cell proliferation | developmental process involved in reproduction | mammary gland duct morphogenesis | morphogenesis of an epithelium | positive regulation of peptidyl-tyrosine phosphorylation | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis | establishment of localization | response to hormone | negative regulation of cellular process | epithelial cell proliferation involved in mammary gland duct elongation | cell differentiation | nervous system development | response to drug | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | membrane organization | response to antibiotic | intracellular transport | response to organophosphorus | cellular process | establishment of organelle localization | localization | epithelial tube morphogenesis | developmental growth | neuron development | response to estradiol | positive regulation of nitrogen compound metabolic process | response to inorganic substance | establishment of localization in cell | response to peptide hormone | tissue development | vesicle targeting, to, from or within Golgi | regulation of cell differentiation | response to hydrogen peroxide | regulation of cellular process | regulation of osteoblast differentiation | regulation of metabolic process | gliogenesis | organelle localization | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | epithelium development | cellular component organization | mammary gland morphogenesis | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | COPII-coated vesicle budding | gland morphogenesis | response to stress | regulation of cell proliferation | tube morphogenesis | response to peptide | reproduction | cellular localization | axis elongation | ERBB signaling pathway | G-protein coupled receptor signaling pathway | cellular component assembly | vesicle targeting | cell-cell signaling | molecular function regulator | response to nitrogen compound | negative regulation of osteoblast differentiation | system development | reproductive process | regulation of signal transduction | multicellular organism development | response to purine-containing compound | mammary gland development | regulation of phosphorylation | regulation of ossification | mammary gland lobule development | vesicle coating | response to lipid | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | response to corticosteroid | vesicle-mediated transport | response to oxidative stress | Golgi vesicle budding | establishment of vesicle localization | cell proliferation | regulation of cellular protein metabolic process | mammary gland epithelial cell proliferation | response to toxic substance | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of cell proliferation | regulation of protein phosphorylation | Golgi vesicle transport | neuron differentiation | regulation of signaling receptor activity | receptor regulator activity | protein-containing complex assembly | positive regulation of protein modification process | response to organic substance | gland development | tissue morphogenesis | branching morphogenesis of an epithelial tube | epithelial cell proliferation | negative regulation of ossification | anatomical structure development | developmental growth involved in morphogenesis | branch elongation of an epithelium | cell surface receptor signaling pathway | growth factor activity | cell projection organization | development of secondary sexual characteristics | receptor ligand activity | development of secondary female sexual characteristics | neuron projection development | cytokine activity | animal organ development | response to reactive oxygen species | mammary gland branching involved in thelarche | regulation of phosphate metabolic process | mammary gland epithelium development | vesicle organization | vesicle budding from membrane | response to cAMP | morphogenesis of a branching epithelium | mammary gland alveolus development | regulation of cell communication | ER to Golgi vesicle-mediated transport | signaling | response to organic cyclic compound | cell development | positive regulation of phosphorylation | morphogenesis of a branching structure | anatomical structure morphogenesis | regulation of developmental process | developmental process | organelle organization | COPII vesicle coating | branch elongation involved in mammary gland duct branching | tube development | response to organonitrogen compound | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | vesicle localization | response to steroid hormone | branching involved in mammary gland duct morphogenesis | negative regulation of cell differentiation | signal transduction | regulation of signaling | response to glucocorticoid | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

endoplasmic reticulum-Golgi intermediate compartment | integral component of membrane | intracellular membrane-bounded organelle | ER to Golgi transport vesicle membrane | organelle membrane | cytoplasmic vesicle | Golgi-associated vesicle membrane | cell | COPII-coated ER to Golgi transport vesicle | intrinsic component of membrane | transport vesicle membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | endoplasmic reticulum-Golgi intermediate compartment membrane | endomembrane system | endoplasmic reticulum membrane | Golgi-associated vesicle | vesicle | transport vesicle | Golgi membrane | extracellular region | coated vesicle membrane | membrane-bounded organelle | nucleus | organelle | vesicle membrane | extracellular space | intracellular vesicle | cell surface | intracellular | membrane | cytoplasmic vesicle membrane | coated vesicle