QuickView for CREBL2 (gene)

Gene Symbol:

CREBL2 Homo sapiens

Full name:

cAMP responsive element binding protein like 2

Synonyms:

cAMP-responsive element-binding protein-like 2, MHBs-binding protein 1

Genomic Location:

Chr 12: 12656098-12689308

Description:

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding prote...

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cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  RTAAACA_FREAC2_01 ,  ATAAGCT_MIR21 ,  TTTGCAC_MIR19A_MIR19B ,  RYTTCCTG_ETS2_B ,  TGGNNNNNNKCCAR_UNKNOWN ,  GATA3_01 ,  FOXO4_01 ,  PEA3_Q6 ,  TGTGTGA_MIR377 ,  SRY_01 ,  GATA1_04 ,  GGGAGGRR_MAZ_Q6 ,  ACATTCC_MIR1_MIR206 ,  GCACCTT_MIR18A_MIR18B ,  FOXO3_01 ,  FREAC3_01 ,  CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6 ,  GATA1_02 ,  FREAC2_01 ,  TTGTTT_FOXO4_01 ,  MYOGENIN_Q6 ,  GAGCCAG_MIR149 ,  CTGAGCC_MIR24 ,  TGACAGNY_MEIS1_01 ,  FOXO4_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-18 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-149

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miRNA binding sites
(Source: miRecords):

hsa-miR-15a/hsa-miR-16 Targeted Genes

Cytogenetic Map:

12p13.1

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