QuickView for CREM (gene)
- Gene Symbol:
- CREM
Homo sapiens - Full name:
- cAMP responsive element modulator
- Synonyms:
- CREM-2, ICER, hCREM-2, cAMP-responsive element modulator, CREM 2alpha-b protein, CREM 2beta-a protein, cAMP response element modulator, inducible cAMP early repressor ICER
- Genomic Location:
- Chr 10: 35455807-35541892
- Description:
-
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exe...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-1 , Predicted Gene Targets for miR-153 , Predicted Gene Targets for miR-199 , Predicted Gene Targets for miR-25 , Predicted Gene Targets for miR-448 , Predicted Gene Targets for miR-376 , Predicted Gene Targets for miR-384 , Predicted Gene Targets for miR-409-3p , Predicted Gene Targets for miR-488
- Cytogenetic Map:
-
10p11.21
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | cAMP response element binding protein binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | positive regulation of macromolecule biosynthetic process | glycosphingolipid metabolic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | glucose metabolic process | cell differentiation | male gamete generation | retinoic acid receptor signaling pathway | positive regulation of cellular biosynthetic process | cellular process | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | sphingolipid metabolic process | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | gamete generation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular lipid metabolic process | response to stimulus | monocarboxylic acid metabolic process | cellular nitrogen compound biosynthetic process | reproduction | rhythmic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | reproductive process | multicellular organism development | lipid metabolic process | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | regulation of transcription by RNA polymerase II | glycolipid metabolic process | biosynthetic process | aromatic compound biosynthetic process | carbohydrate metabolic process | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | carboxylic acid metabolic process | multicellular organism reproduction | DNA-binding transcription factor activity | anatomical structure development | metabolic process | membrane lipid metabolic process | regulation of RNA biosynthetic process | hexose metabolic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | fatty acid metabolic process | transcription, DNA-templated | intracellular receptor signaling pathway | signaling | regulation of transcription, DNA-templated | organic acid metabolic process | cellular macromolecule biosynthetic process | regulation of circadian rhythm | developmental process | spermatogenesis | negative regulation of transcription by RNA polymerase II | carbohydrate derivative metabolic process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | sexual reproduction | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | membrane-bounded organelle | nucleus | organelle | intracellular
