QuickView for CRYZ (gene)

Gene Symbol:

CRYZ Homo sapiens

Full name:

crystallin zeta

Synonyms:

quinone oxidoreductase, NADPH:quinone reductase, crystallin, zeta (quinone reductase)

Genomic Location:

Chr 1: 74943772-74971315

Description:

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein ...

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Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Cytogenetic Map:

1p31.1

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