QuickView for CS (gene)

Gene Symbol:

CS Homo sapiens

Full name:

citrate synthase

Synonyms:

citrate synthase, mitochondrial, citrate (Si)-synthase

Genomic Location:

Chr 12: 54951750-54980442

Description:

The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found.

The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metablism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTTGCAC_MIR19A_MIR19B ,  TFIIA_Q6 ,  HNF1_01 ,  ACACTCC_MIR122A ,  STAT1_02 ,  TCANNTGAY_SREBP1_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  HOXA4_Q2 ,  GATA_Q6 ,  YGTCCTTGR_UNKNOWN ,  HP1SITEFACTOR_Q6 ,  GTAAACC_MIR2995P ,  GATAAGR_GATA_C ,  CTTTGA_LEF1_Q2 ,  STAT1_03 ,  TGACCTY_ERR1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  TCTAGAG_MIR517 ,  CDP_02 ,  PAX4_02 ,  CEBP_01 ,  SP1_Q4_01 ,  GGGCGGR_SP1_Q6 ,  GATA6_01 ,  S8_01 ,  CTTTAAR_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  GATA1_02 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  WWTAAGGC_UNKNOWN ,  CP2_02 ,  CTCTAGA_MIR526C_MIR518F_MIR526A ,  CTTTGT_LEF1_Q2 ,  AGGCACT_MIR5153P ,  BRN2_01 ,  PAX4_03 ,  HNF1_Q6 ,  TGACCTTG_SF1_Q6 ,  GGGTGGRR_PAX4_03 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-421

Cytogenetic Map:

12q13.3

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