QuickView for CSK (gene)
- Gene Symbol:
- CSK
Homo sapiens - Full name:
- C-terminal Src kinase
- Synonyms:
- tyrosine-protein kinase CSK, C-Src kinase, CSK, non-receptor tyrosine kinase, c-src tyrosine kinase, protein-tyrosine kinase CYL
- Genomic Location:
- Chr 15: 72861768-72882558
- Description:
-
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on ...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
15q24.1
GO Molecular Function
kinase binding | cation binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | proline-rich region binding | protein kinase A catalytic subunit binding | anion binding | adenyl nucleotide binding | protein kinase A binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | protein phosphatase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | metal ion binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding
GO Biological Process
positive regulation of immune response | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | brain development | adaptive immune response | negative regulation of MAPK cascade | immune response-regulating signaling pathway | regulation of cellular localization | regulation of localization | peptidyl-amino acid modification | negative regulation of phagocytosis | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | positive regulation of lymphocyte activation | regulation of protein localization to membrane | cell differentiation | immune response-activating cell surface receptor signaling pathway | negative regulation of tissue remodeling | T cell receptor signaling pathway | nervous system development | lymphocyte costimulation | negative regulation of protein phosphorylation | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of bone remodeling | cellular process | negative regulation of signaling | negative regulation of protein localization to plasma membrane | positive regulation of protein kinase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | response to peptide hormone | regulation of immune response | regulation of cellular process | regulation of metabolic process | gliogenesis | regulation of Golgi to plasma membrane protein transport | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | negative regulation of bone resorption | cellular component organization | head development | response to stimulus | negative regulation of protein transport | regulation of Fc receptor mediated stimulatory signaling pathway | regulation of cellular protein localization | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of cell proliferation | response to peptide | positive regulation of cell-cell adhesion | negative regulation of low-density lipoprotein particle clearance | positive regulation of cell activation | positive regulation of T cell activation | immune response-activating signal transduction | negative regulation of transport | regulation of phagocytosis | regulation of protein transport | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | protein modification process | regulation of peptide transport | regulation of cell adhesion | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | response to nitrogen compound | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | adherens junction organization | negative regulation of interleukin-6 production | multicellular organism development | negative regulation of catalytic activity | cellular response to peptide hormone stimulus | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | negative regulation of cellular protein localization | regulation of T cell activation | cellular response to peptide | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | regulation of cellular protein metabolic process | glial cell differentiation | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | negative regulation of Golgi to plasma membrane protein transport | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | protein tyrosine kinase activity | positive regulation of molecular function | activation of immune response | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | negative regulation of endocytosis | metabolic process | regulation of protein localization to plasma membrane | positive regulation of leukocyte activation | regulation of bone resorption | oligodendrocyte differentiation | regulation of tissue remodeling | regulation of vesicle-mediated transport | immune response | protein kinase activity | organic substance metabolic process | animal organ development | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of kinase activity | regulation of phosphate metabolic process | antigen receptor-mediated signaling pathway | positive regulation of MAPK cascade | negative regulation of protein metabolic process | T cell costimulation | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of endocytosis | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | positive regulation of MAP kinase activity | kinase activity | developmental process | cellular protein modification process | regulation of transport | negative regulation of cell proliferation | regulation of cell-cell adhesion | response to organonitrogen compound | regulation of low-density lipoprotein particle clearance | central nervous system development | negative regulation of bone remodeling | positive regulation of metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of interleukin-6 production | positive regulation of leukocyte cell-cell adhesion | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
cell | cytoplasm | membrane microdomain | cell-cell junction | plasma membrane | membrane raft | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | cytosol | intracellular | cell junction | membrane
