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QuickView for CTLA4;jsessionid=B923534A2CE31A0634BFB2C142F1D6FE (gene)


Gene Symbol:
CTLA4 Homo sapiens Homo sapiens
Full name:
cytotoxic T-lymphocyte associated protein 4
Synonyms:
ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte protein 4, CD152 isoform, celiac disease 3, cytotoxic T lymphocyte associated antigen 4 short spliced form, cytotoxic T-lymphocyte-associated serine esterase-4, insulin-dependent diabetes mellitus 12, ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Genomic Location:
Chr 2: 204440754-204446928
Description:
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a hom...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q33.2





GO Molecular Function

protein binding

GO Biological Process

positive regulation of immune response | negative regulation of lymphocyte differentiation | negative regulation of leukocyte activation | adaptive immune response | negative regulation of immune system process | regulation of B cell activation | immune response-regulating signaling pathway | positive regulation of apoptotic process | regulation of programmed cell death | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of lymphocyte activation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | negative regulation of B cell proliferation | lymphocyte costimulation | positive regulation of cell adhesion | cellular process | negative regulation of T cell proliferation | regulation of cell differentiation | regulation of immune response | regulation of cellular process | regulation of apoptotic process | negative regulation of mononuclear cell proliferation | response to stimulus | regulation of regulatory T cell differentiation | positive regulation of immune system process | negative regulation of cell adhesion | response to stress | negative regulation of lymphocyte activation | regulation of cell proliferation | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | immune response-activating signal transduction | negative regulation of hemopoiesis | regulation of cell adhesion | B cell receptor signaling pathway | regulation of lymphocyte differentiation | cellular response to DNA damage stimulus | regulation of T cell activation | cellular response to stress | regulation of lymphocyte activation | negative regulation of T cell activation | negative regulation of immune response | negative regulation of cell-cell adhesion | cell communication | negative regulation of cell activation | negative regulation of T cell differentiation | negative regulation of B cell activation | activation of immune response | regulation of hemopoiesis | cell surface receptor signaling pathway | negative regulation of leukocyte proliferation | positive regulation of leukocyte activation | positive regulation of cell death | immune response | regulation of cell activation | positive regulation of programmed cell death | antigen receptor-mediated signaling pathway | T cell costimulation | signaling | regulation of T cell proliferation | regulation of developmental process | regulation of B cell proliferation | negative regulation of cell proliferation | regulation of cell-cell adhesion | negative regulation of lymphocyte proliferation | immune system process | regulation of cell death | positive regulation of leukocyte cell-cell adhesion | negative regulation of cell differentiation | signal transduction | negative regulation of regulatory T cell differentiation

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | clathrin-coated vesicle | cytoplasmic vesicle | cell | intrinsic component of membrane | external side of plasma membrane | cytoplasm | clathrin-coated endocytic vesicle | intracellular organelle | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | vesicle | perinuclear region of cytoplasm | integral component of plasma membrane | membrane-bounded organelle | organelle | cell periphery | protein complex involved in cell adhesion | intracellular vesicle | cell surface | endocytic vesicle | intracellular | membrane | intrinsic component of plasma membrane | coated vesicle