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QuickView for CTNNB1 (gene)


Gene Symbol:
CTNNB1 Homo sapiens Homo sapiens
Full name:
catenin beta 1
Synonyms:
CTNNB, EVR7, MRD19, armadillo, catenin beta-1, catenin (cadherin-associated protein), beta 1, 88kDa
Genomic Location:
Chr 3: 41215946-41256943
Description:
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inh...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3p22.1





GO Molecular Function

kinase binding | cadherin binding | hormone receptor binding | enzyme binding | RNA polymerase II activating transcription factor binding | estrogen receptor binding | signaling receptor binding | chromatin binding | ion channel binding | androgen receptor binding | nuclear hormone receptor binding | cell adhesion molecule binding | transcription coactivator activity | I-SMAD binding | protein binding | protein phosphatase binding | transcription factor binding | alpha-catenin binding | RNA polymerase II transcription factor binding | activating transcription factor binding | steroid hormone receptor binding | phosphatase binding | transcription coregulator activity | SMAD binding | protein C-terminus binding

GO Biological Process

RNA metabolic process | brain development | limb development | regulation of epithelial cell differentiation involved in kidney development | cell morphogenesis | sympathetic ganglion development | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | negative regulation of embryonic development | positive regulation of cellular component organization | regulation of neurogenesis | neuron projection morphogenesis | regulation of cellular localization | positive regulation of apoptotic process | regulation of cell development | regulation of localization | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | cellular response to indole-3-methanol | embryonic skeletal joint morphogenesis | response to hormone | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | negative regulation of mitotic cell cycle, embryonic | microtubule cytoskeleton organization | cell differentiation | adherens junction assembly | nervous system development | epithelial to mesenchymal transition | response to drug | androgen receptor signaling pathway | canonical Wnt signaling pathway involved in regulation of cell proliferation | cell part morphogenesis | neurogenesis | regulation of organelle organization | generation of neurons | mesenchyme development | regulation of neuroblast proliferation | hormone-mediated signaling pathway | microtubule-based process | blood vessel morphogenesis | regulation of neuron death | neuron projection extension | regulation of chromosome segregation | positive regulation of cellular biosynthetic process | cellular process | positive regulation of glycoprotein biosynthetic process | localization | cell projection morphogenesis | epithelial tube morphogenesis | limb morphogenesis | developmental growth | neuron development | central nervous system neuron differentiation | canonical Wnt signaling pathway | response to estradiol | beta-catenin destruction complex disassembly | positive regulation of epithelial to mesenchymal transition | regulation of embryonic development | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | macromolecule localization | regulation of histone modification | negative regulation of apoptotic process | microtubule organizing center organization | regulation of cell cycle | response to growth factor | positive regulation of nitrogen compound metabolic process | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | interspecies interaction between organisms | positive regulation of muscle cell differentiation | cell junction assembly | autonomic nervous system development | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | regulation of protein complex assembly | regulation of nephron tubule epithelial cell differentiation | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | entry into host cell | canonical Wnt signaling pathway involved in negative regulation of apoptotic process | head development | regulation of type I interferon production | regulation of histone methylation | branching involved in blood vessel morphogenesis | regulation of vasculature development | response to stimulus | positive regulation of heparan sulfate proteoglycan biosynthetic process | vasculature development | regulation of centriole-centriole cohesion | regulation of glycoprotein biosynthetic process | regulation of cellular protein localization | embryonic limb morphogenesis | regulation of centrosome cycle | positive regulation of protein metabolic process | ganglion development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of neuroblast proliferation | negative regulation of angiogenesis | tube morphogenesis | regulation of epithelial cell differentiation | beta-catenin-TCF complex assembly | regulation of transcription regulatory region DNA binding | cellular localization | embryonic skeletal system development | response to alcohol | cardiovascular system development | midbrain development | cellular nitrogen compound metabolic process | regulation of DNA binding | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | steroid hormone mediated signaling pathway | cellular biosynthetic process | embryo development | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | blood vessel development | hair cell differentiation | regulation of nucleic acid-templated transcription | response to nitrogen compound | embryonic skeletal joint development | cellular response to hormone stimulus | canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | system development | canonical Wnt signaling pathway involved in heart development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | endothelium development | Wnt signaling pathway | adherens junction organization | multicellular organism development | regulation of protein localization to cell surface | regulation of mitotic cell cycle, embryonic | positive regulation of chromosome organization | regulation of gene expression | response to lipid | cell cycle | entry of bacterium into host cell | regulation of stem cell proliferation | positive regulation of cellular metabolic process | animal organ morphogenesis | canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation | regulation of nitrogen compound metabolic process | positive regulation of protein complex assembly | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | non-canonical Wnt signaling pathway | epidermal cell differentiation | regulation of cell proliferation involved in heart morphogenesis | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | angiogenesis | regulation of centromeric sister chromatid cohesion | positive regulation of neuron death | epidermis development | protein localization to cell surface | regulation of protein sumoylation | cellular response to drug | chordate embryonic development | cell communication | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | regulation of core promoter binding | sympathetic nervous system development | regulation of neuron apoptotic process | skeletal system morphogenesis | regulation of protein metabolic process | regulation of histone H3-K4 methylation | heart development | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition | embryonic morphogenesis | regulation of mitotic cell cycle | regulation of microtubule-based process | positive regulation of molecular function | regulation of sister chromatid cohesion | neuron differentiation | embryonic organ morphogenesis | Wnt signaling pathway, calcium modulating pathway | protein-containing complex assembly | regulation of fibroblast proliferation | positive regulation of protein modification process | response to organic substance | tissue morphogenesis | centrosome cycle | branching morphogenesis of an epithelial tube | response to antineoplastic agent | regulation of animal organ morphogenesis | regulation of DNA-binding transcription factor activity | regulation of sister chromatid segregation | positive regulation of neuron apoptotic process | anatomical structure development | developmental growth involved in morphogenesis | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | embryonic skeletal system morphogenesis | endothelial tube morphogenesis | cell projection organization | metabolic process | positive regulation of cell development | mesenchymal cell differentiation | positive regulation of DNA-templated transcription, initiation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | negative regulation of mitotic cell cycle | cellular protein localization | positive regulation of cell death | cell adhesion | midbrain dopaminergic neuron differentiation | nucleobase-containing compound metabolic process | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | maintenance of cell number | positive regulation of core promoter binding | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | positive regulation of proteoglycan biosynthetic process | positive regulation of programmed cell death | regulation of heart morphogenesis | regulation of Wnt signaling pathway | cytoskeleton organization | regulation of chromosome organization | cellular response to steroid hormone stimulus | positive regulation of binding | positive regulation of glycoprotein metabolic process | cell-cell adhesion | transcription, DNA-templated | positive regulation of cytokine production | dopaminergic neuron differentiation | intracellular receptor signaling pathway | morphogenesis of a branching epithelium | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | negative regulation of protein metabolic process | negative regulation of protein sumoylation | regulation of calcium ion import | regulation of cell communication | signaling | limb joint morphogenesis | regulation of transcription, DNA-templated | response to organic cyclic compound | response to indole-3-methanol | cell development | positive regulation of DNA binding | protein localization | protein-containing complex disassembly | regulation of cytokine production | morphogenesis of a branching structure | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of stem cell proliferation | regulation of DNA-templated transcription, initiation | regulation of nervous system development | regulation of developmental process | regulation of ion transport | positive regulation of neural precursor cell proliferation | developmental process | organelle organization | regulation of muscle cell differentiation | regulation of calcium ion transport | intracellular steroid hormone receptor signaling pathway | tube development | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | developmental cell growth | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | transcription coregulator activity | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | skeletal system development | positive regulation of histone methylation | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of type I interferon production | response to steroid hormone | negative regulation of cell death | circulatory system development | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | embryonic skeletal limb joint morphogenesis | signal transduction | regulation of signaling | positive regulation of gene expression | positive regulation of transcription regulatory region DNA binding | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization

GO Cellular Component

nuclear euchromatin | nuclear transcription factor complex | chromosome | catenin-TCF7L2 complex | intracellular membrane-bounded organelle | synapse | extrinsic component of membrane | catenin complex | adherens junction | Wnt signalosome | microtubule organizing center | RNA polymerase II transcription factor complex | focal adhesion | cell | nuclear lumen | plasma membrane protein complex | extrinsic component of plasma membrane | transcription factor complex | cytoplasm | spindle | cell-substrate junction | intracellular organelle | cell-cell adherens junction | centrosome | cell-cell junction | euchromatin | protein-containing complex | cell projection | protein-DNA complex | nucleoplasm | plasma membrane | chromatin | nuclear chromosome | vesicle | perinuclear region of cytoplasm | extracellular exosome | microtubule cytoskeleton | cytoplasmic region | beta-catenin destruction complex | spindle pole | beta-catenin-TCF7L2 complex | beta-catenin-TCF complex | extracellular region | cell cortex | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | membrane-enclosed lumen | basolateral plasma membrane | cell-substrate adherens junction | nuclear chromatin | cytosol | cytoskeleton | intracellular | cell junction | lateral plasma membrane | membrane