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QuickView for CTSB%3Bjsessionid%3D39A2EA10DF6587251E49AE65A487A927 (gene)


Gene Symbol:
CTSB Homo sapiens Homo sapiens
Full name:
cathepsin B
Synonyms:
APPS, CPSB, cathepsin B, APP secretase, amyloid precursor protein secretase, cathepsin B1, cysteine protease
Genomic Location:
Chr 8: 11737442-11763055
Description:
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to for...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Bos taurus Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8
8p23.1





GO Molecular Function

proteoglycan binding | protein-containing complex binding | hydrolase activity | carbohydrate derivative binding | cysteine-type peptidase activity | catalytic activity | serine hydrolase activity | collagen binding | cysteine-type endopeptidase activity | protein binding | serine-type endopeptidase activity | serine-type peptidase activity | endopeptidase activity | peptidase activity

GO Biological Process

exocytosis | neutrophil activation | developmental process involved in reproduction | proteolysis | regulation of programmed cell death | establishment of localization | response to hormone | cell differentiation | maternal placenta development | cellular process | secretion | organic substance catabolic process | leukocyte degranulation | localization | proteolysis involved in cellular protein catabolic process | reproductive system development | female pregnancy | multicellular organismal reproductive process | tissue development | interspecies interaction between organisms | regulation of cellular process | leukocyte activation | regulation of apoptotic process | catabolic process | epithelium development | entry into host cell | viral life cycle | response to stimulus | neutrophil degranulation | collagen catabolic process | leukocyte activation involved in immune response | reproduction | cellular protein catabolic process | secretion by cell | cysteine-type peptidase activity | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | reproductive process | multicellular organism development | leukocyte mediated immunity | regulation of catalytic activity | viral entry into host cell | protein catabolic process | vesicle-mediated transport | regulated exocytosis | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | cysteine-type endopeptidase activity | viral process | decidualization | multicellular organism reproduction | maternal process involved in female pregnancy | cellular response to thyroid hormone stimulus | protein metabolic process | response to organic substance | cellular macromolecule catabolic process | anatomical structure development | metabolic process | immune response | organic substance metabolic process | animal organ development | serine-type endopeptidase activity | serine-type peptidase activity | cell activation | organonitrogen compound catabolic process | endopeptidase activity | cellular protein metabolic process | collagen metabolic process | reproductive structure development | developmental process | response to thyroid hormone | neutrophil mediated immunity | epithelial cell differentiation | immune system process | cellular metabolic process | placenta development | peptidase activity | cellular response to organic substance | regulation of cell death | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | endolysosome | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | nuclear lumen | vacuolar lumen | nucleolus | cytoplasm | intracellular organelle | ficolin-1-rich granule lumen | melanosome | secretory vesicle | endomembrane system | vacuole | vesicle | perinuclear region of cytoplasm | endolysosome lumen | extracellular exosome | lytic vacuole | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | endosome lumen | nucleus | organelle | lysosome | extracellular space | membrane-enclosed lumen | lysosomal lumen | intracellular vesicle | intracellular