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QuickView for CUL3 (gene)


Gene Symbol:
CUL3 Homo sapiens Homo sapiens
Full name:
cullin 3
Synonyms:
CUL-3, PHA2E, cullin-3
Genomic Location:
Chr 2: 225043113-225158358
Description:
This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation....
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q36.2





GO Molecular Function

POZ domain binding | cyclin binding | enzyme binding | signaling receptor binding | Notch binding | catalytic activity | protein domain specific binding | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | identical protein binding | ubiquitin protein ligase activity | protein heterodimerization activity | protein binding | protein homodimerization activity | ubiquitin protein ligase binding | protein dimerization activity | ubiquitin-protein transferase activity | transferase activity | ubiquitin-like protein ligase activity

GO Biological Process

cell morphogenesis | regulation of cell cycle process | blastocyst formation | actin filament-based process | positive regulation of cellular component organization | cell motility | intracellular signal transduction | proteolysis | actin filament bundle organization | actin cytoskeleton organization | establishment of localization | fibroblast apoptotic process | negative regulation of cellular process | integrin-mediated signaling pathway | negative regulation of RNA biosynthetic process | cell differentiation | response to misfolded protein | regulation of organelle organization | membrane organization | intracellular transport | regulation of chromosome segregation | cellular process | organic substance catabolic process | establishment of organelle localization | nuclear protein quality control by the ubiquitin-proteasome system | localization | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | regulation of mitotic nuclear division | negative regulation of nucleic acid-templated transcription | regulation of chromosome separation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | regulation of canonical Wnt signaling pathway | establishment of localization in cell | negative regulation of cellular metabolic process | vesicle targeting, to, from or within Golgi | intrinsic apoptotic signaling pathway | positive regulation of cytokinesis | regulation of cellular process | regulation of metabolic process | catabolic process | organelle localization | hepaticobiliary system development | positive regulation of cell cycle phase transition | positive regulation of cellular protein metabolic process | response to topologically incorrect protein | cellular component organization | establishment of chromosome localization | MAPK cascade | cellular response to topologically incorrect protein | regulation of cell division | response to stimulus | regulation of mitotic cell cycle phase transition | chromosome segregation | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | COPII-coated vesicle budding | gland morphogenesis | response to stress | regulation of cell proliferation | regulation of protein ubiquitination | anaphase-promoting complex-dependent catabolic process | regulation of cell cycle phase transition | programmed cell death | protein destabilization | supramolecular fiber organization | cellular protein catabolic process | cellular localization | proteasomal protein catabolic process | cell cycle G1/S phase transition | negative regulation of metabolic process | cellular component assembly | protein modification process | embryo development | macromolecule modification | vesicle targeting | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | locomotion | apoptotic process | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | Wnt signaling pathway | protein monoubiquitination | regulation of protein stability | multicellular organism development | cell migration | positive regulation of mitotic metaphase/anaphase transition | positive regulation of chromosome separation | sister chromatid segregation | phosphorus metabolic process | actin filament organization | liver morphogenesis | positive regulation of chromosome organization | trophectodermal cell differentiation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of small GTPase mediated signal transduction | regulation of gene expression | vesicle coating | cellular response to stress | cell cycle | protein catabolic process | stem cell division | positive regulation of cellular metabolic process | mitotic metaphase plate congression | animal organ morphogenesis | liver development | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | vesicle-mediated transport | regulation of transcription by RNA polymerase II | actin filament bundle assembly | ubiquitin protein ligase activity | Golgi vesicle budding | regulation of Rho protein signal transduction | establishment of vesicle localization | cell division | metaphase plate congression | regulation of cellular protein metabolic process | phosphorylation | actomyosin structure organization | mitotic cell cycle phase transition | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | nuclear chromosome segregation | chordate embryonic development | cell communication | regulation of cellular metabolic process | regulation of cytokinesis | trophectodermal cellular morphogenesis | contractile actin filament bundle assembly | regulation of protein metabolic process | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | Golgi vesicle transport | regulation of RNA metabolic process | apoptotic signaling pathway | embryonic morphogenesis | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | protein polyubiquitination | protein-containing complex assembly | protein metabolic process | positive regulation of protein modification process | response to organic substance | gland development | protein ubiquitination | cell cycle arrest | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | regulation of sister chromatid segregation | anatomical structure development | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | cell surface receptor signaling pathway | nuclear division | cell projection organization | metabolic process | ubiquitin-protein transferase activity | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | protein quality control for misfolded or incompletely synthesized proteins | negative regulation of Rho protein signal transduction | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of small GTPase mediated signal transduction | positive regulation of chromosome segregation | negative regulation of Ras protein signal transduction | protein modification by small protein conjugation or removal | regulation of Wnt signaling pathway | cytoskeleton organization | regulation of chromosome organization | mitotic nuclear division | vesicle organization | blastocyst development | vesicle budding from membrane | embryonic cleavage | ubiquitin-dependent protein catabolic process | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | organonitrogen compound catabolic process | regulation of mitotic sister chromatid segregation | regulation of cell communication | ER to Golgi vesicle-mediated transport | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cell development | cellular protein metabolic process | regulation of Ras protein signal transduction | anatomical structure morphogenesis | stress fiber assembly | developmental process | negative regulation of canonical Wnt signaling pathway | organelle organization | COPII vesicle coating | positive regulation of cell cycle process | cellular protein modification process | positive regulation of mitotic sister chromatid separation | negative regulation of transcription by RNA polymerase II | regulation of mitotic metaphase/anaphase transition | cell cycle phase transition | in utero embryonic development | positive regulation of metabolic process | chromosome organization | cellular response to misfolded protein | negative regulation of Wnt signaling pathway | vesicle localization | gastrulation | cellular metabolic process | cellular response to organic substance | modification-dependent protein catabolic process | mitotic sister chromatid segregation | positive regulation of protein ubiquitination | regulation of cellular component organization | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | post-translational protein modification | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

sperm flagellum | supramolecular fiber | intracellular membrane-bounded organelle | catalytic complex | organelle membrane | cell | nuclear lumen | Cul3-RING ubiquitin ligase complex | microtubule | cytoplasm | spindle | intracellular organelle | 9+2 motile cilium | motile cilium | ubiquitin ligase complex | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | nucleoplasm | cilium | vesicle | transferase complex | extracellular exosome | microtubule cytoskeleton | spindle pole | spindle microtubule | Golgi membrane | extracellular region | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | polar microtubule | cytosol | cytoskeleton | intracellular | membrane | supramolecular complex