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QuickView for CUL4A (gene)


Gene Symbol:
CUL4A Homo sapiens Homo sapiens
Full name:
cullin 4A
Synonyms:
cullin-4A, CUL-4A
Genomic Location:
Chr 13: 112911087-112967393
Description:
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 13
13q34





GO Molecular Function

enzyme binding | catalytic activity | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | ubiquitin protein ligase activity | protein binding | ubiquitin protein ligase binding | ubiquitin-protein transferase activity | transferase activity | ubiquitin-like protein ligase activity

GO Biological Process

regulation of cell cycle process | negative regulation of immune system process | detection of stimulus | nucleotide-excision repair, DNA damage recognition | positive regulation of cellular component organization | intracellular signal transduction | proteolysis | regulation of cell cycle G1/S phase transition | somatic stem cell population maintenance | positive regulation of G1/S transition of mitotic cell cycle | regulation of immune system process | negative regulation of cellular process | regulation of G1/S transition of mitotic cell cycle | regulation of DNA repair | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | immune system development | global genome nucleotide-excision repair | stem cell population maintenance | regulation of cell cycle | regulation of myeloid cell differentiation | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | interspecies interaction between organisms | intrinsic apoptotic signaling pathway | regulation of cellular process | regulation of metabolic process | catabolic process | regulation of protein complex assembly | negative regulation of granulocyte differentiation | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | regulation of mitotic cell cycle phase transition | response to stress | regulation of cell proliferation | regulation of granulocyte differentiation | regulation of cell cycle phase transition | programmed cell death | protein-DNA complex assembly | cellular protein catabolic process | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | cell cycle G1/S phase transition | nucleic acid phosphodiester bond hydrolysis | hemopoiesis | cellular component assembly | negative regulation of hemopoiesis | protein modification process | embryo development | macromolecule modification | DNA repair | regulation of cellular response to stress | apoptotic process | system development | nitrogen compound metabolic process | multicellular organism development | cellular response to DNA damage stimulus | nucleotide-excision repair, DNA incision, 5'-to lesion | positive regulation of cell cycle | positive regulation of mitotic cell cycle | cellular response to stress | cell cycle | protein catabolic process | negative regulation of myeloid cell differentiation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | positive regulation of protein complex assembly | ubiquitin protein ligase activity | regulation of DNA damage checkpoint | cellular protein-containing complex assembly | nucleotide-excision repair, preincision complex stabilization | mitotic cell cycle phase transition | positive regulation of cell cycle G1/S phase transition | chordate embryonic development | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | viral process | apoptotic signaling pathway | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | protein-containing complex assembly | protein metabolic process | protein ubiquitination | regulation of hemopoiesis | cell cycle arrest | DNA metabolic process | cellular macromolecule catabolic process | nucleotide-excision repair, DNA incision | anatomical structure development | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | DNA damage response, detection of DNA damage | metabolic process | nucleotide-excision repair | ubiquitin-protein transferase activity | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | positive regulation of cellular component biogenesis | regulation of nucleotide-excision repair | organic substance metabolic process | maintenance of cell number | cell death | animal organ development | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | organonitrogen compound catabolic process | transcription-coupled nucleotide-excision repair | signaling | cellular protein metabolic process | regulation of developmental process | developmental process | organelle organization | positive regulation of cell cycle process | cellular protein modification process | negative regulation of cell proliferation | cell cycle phase transition | heterocycle metabolic process | in utero embryonic development | chromosome organization | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | modification-dependent protein catabolic process | negative regulation of myeloid leukocyte differentiation | negative regulation of cell differentiation | regulation of cellular component organization | signal transduction | nucleotide-excision repair, preincision complex assembly | post-translational protein modification | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | intracellular organelle | ubiquitin ligase complex | protein-containing complex | nucleoplasm | transferase complex | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | Cul4-RING E3 ubiquitin ligase complex | Cul4A-RING E3 ubiquitin ligase complex | intracellular