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QuickView for CX3CR1 (gene)


Gene Symbol:
CX3CR1 Homo sapiens Homo sapiens
Full name:
C-X3-C motif chemokine receptor 1
Synonyms:
CCRL1, CMKBRL1, CMKDR1, GPR13, GPRV28, V28, CX3C chemokine receptor 1, C-X3-C CKR-1, CMK-BRL-1, CMK-BRL1, G-protein coupled receptor 13, beta chemokine receptor-like 1, chemokine (C-C) receptor-like 1, chemokine (C-X3-C motif) receptor 1, chemokine (C-X3-C) receptor 1, fractalkine receptor
Genomic Location:
Chr 3: 39279989-39296531
Description:
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transc...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 3
3p22.2





GO Molecular Function

cytokine binding | C-X3-C chemokine receptor activity | transmembrane signaling receptor activity | G-protein coupled receptor activity | chemokine binding | C-X3-C chemokine binding | signaling receptor activity | G-protein coupled chemoattractant receptor activity | cytokine receptor activity | protein binding | C-C chemokine receptor activity | peptide receptor activity | chemokine receptor activity | G-protein coupled peptide receptor activity | C-C chemokine binding

GO Biological Process

brain development | regulation of extrinsic apoptotic signaling pathway in absence of ligand | macrophage chemotaxis | macrophage migration | response to cytokine | cell motility | regulation of neurogenesis | response to lipopolysaccharide | intracellular signal transduction | autocrine signaling | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | regulation of immune system process | regulation of nitric oxide biosynthetic process | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | chemokine-mediated signaling pathway | defense response | nervous system development | negative regulation of hippocampal neuron apoptotic process | cellular chemical homeostasis | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | regulation of neuroblast proliferation | regulation of neuron death | cellular process | C-X3-C chemokine receptor activity | regulation of cytokine biosynthetic process | regulation of cell motility | localization | cellular homeostasis | forebrain cell migration | negative regulation of signaling | negative regulation of apoptotic process | response to growth factor | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of apoptotic signaling pathway | negative regulation of cell motility | regulation of angiogenesis | regulation of protein kinase B signaling | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | leukocyte tethering or rolling | regulation of metabolic process | regulation of cytosolic calcium ion concentration | cellular response to molecule of bacterial origin | positive regulation of cellular protein metabolic process | calcium ion homeostasis | response to transforming growth factor beta | head development | G-protein coupled receptor activity | regulation of vasculature development | response to stimulus | positive regulation of I-kappaB phosphorylation | regulation of long-term synaptic potentiation | positive regulation of protein metabolic process | response to stress | leukocyte activation involved in immune response | regulation of cell proliferation | positive regulation of neuroblast proliferation | negative regulation of angiogenesis | telencephalon cell migration | response to molecule of bacterial origin | response to ischemia | G-protein coupled receptor signaling pathway | modulation of chemical synaptic transmission | cell-cell signaling | microglial cell activation involved in immune response | cell chemotaxis | metal ion homeostasis | leukocyte migration | regulation of nucleic acid-templated transcription | regulation of glial cell migration | regulation of neurotransmitter levels | locomotion | negative regulation of neuron apoptotic process | response to external biotic stimulus | system development | regulation of signal transduction | multicellular organism development | cell migration | learning or memory | positive regulation of protein kinase B signaling | regulation of phosphorylation | telencephalon development | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | response to lipid | nervous system process | regulation of stem cell proliferation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | G-protein coupled chemoattractant receptor activity | positive regulation of cell differentiation | second-messenger-mediated signaling | negative regulation of extrinsic apoptotic signaling pathway | cognition | macrophage activation involved in immune response | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | regulation of apoptotic signaling pathway | microglial cell activation | cerebral cortex cell migration | regulation of tumor necrosis factor production | cation homeostasis | regulation of leukocyte migration | cytokine receptor activity | response to bacterium | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | viral process | cerebral cortex development | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | calcium-mediated signaling | positive regulation of protein modification process | response to organic substance | leukocyte adhesion to vascular endothelial cell | response to wounding | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | leukocyte cell-cell adhesion | positive regulation of cell development | regulation of RNA biosynthetic process | negative regulation of long-term synaptic potentiation | negative regulation of programmed cell death | chemical homeostasis | behavior | cell adhesion | macrophage activation | immune response | regulation of tumor necrosis factor biosynthetic process | animal organ development | forebrain development | pallium development | negative regulation of cellular component movement | positive regulation of NF-kappaB transcription factor activity | ion homeostasis | regulation of phosphate metabolic process | phospholipase C-activating G-protein coupled receptor signaling pathway | cell-cell adhesion | cell activation | regulation of reactive oxygen species biosynthetic process | memory | C-C chemokine receptor activity | regulation of cell communication | regulation of gliogenesis | negative regulation of signal transduction | chemokine receptor activity | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | G-protein coupled peptide receptor activity | regulation of transcription, DNA-templated | positive regulation of phosphorylation | regulation of cytokine production | positive regulation of stem cell proliferation | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | positive regulation of neural precursor cell proliferation | developmental process | cellular extravasation | regulation of reactive oxygen species metabolic process | innate immune response | negative regulation of vasculature development | cellular defense response | cellular metal ion homeostasis | central nervous system development | positive regulation of metabolic process | regulation of synaptic plasticity | immune system process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | chemotaxis | divalent inorganic cation homeostasis | negative regulation of locomotion | regulation of microglial cell migration | positive regulation of angiogenesis | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | cell body | cell | nuclear lumen | neuronal cell body | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | dendritic tree | cell projection | nucleoplasm | plasma membrane | neuronal cell body membrane | perinuclear region of cytoplasm | integral component of plasma membrane | membrane-bounded organelle | nucleus | organelle | cell periphery | cell body membrane | membrane-enclosed lumen | cell surface | intracellular | membrane | intrinsic component of plasma membrane