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QuickView for CXCL10;jsessionid=DBD61CA45A8F05E6B5DA177159229349 (gene)


Gene Symbol:
CXCL10 Homo sapiens Homo sapiens
Full name:
C-X-C motif chemokine ligand 10
Synonyms:
C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, chemokine (C-X-C motif) ligand 10, gamma IP10, interferon-inducible cytokine IP-10, protein 10 from interferon (gamma)-induced cell line, small inducible cytokine subfamily B (Cys-X-Cys), member 10, small-inducible cytokine B10
Genomic Location:
Chr 4: 77161295-77163674
Description:
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 4
4q21.1


Transcripts Names
NM_001565
Protein Names
A0A024RDA4
P02778
Q96QJ5



GO Molecular Function

protein kinase regulator activity | chemokine activity | kinase regulator activity | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | CXCR chemokine receptor binding | molecular function regulator | anion binding | ion binding | CXCR3 chemokine receptor binding | chemokine receptor binding | cAMP-dependent protein kinase regulator activity | heparin binding | protein binding | receptor regulator activity | G-protein coupled receptor binding | receptor ligand activity | cytokine activity | glycosaminoglycan binding | enzyme regulator activity

GO Biological Process

positive regulation of release of sequestered calcium ion into cytosol | response to extracellular stimulus | regulation of leukocyte chemotaxis | regulation of myoblast fusion | response to radiation | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to virus | response to nutrient levels | response to cytokine | cell motility | response to lipopolysaccharide | regulation of cellular localization | intracellular signal transduction | regulation of localization | protein kinase regulator activity | defense response to other organism | regulation of immune system process | negative regulation of cellular process | chemokine-mediated signaling pathway | defense response | cellular chemical homeostasis | positive regulation of cellular component movement | positive regulation of cellular biosynthetic process | cellular process | regulation of cell motility | localization | cellular homeostasis | regulation of syncytium formation by plasma membrane fusion | chemokine activity | kinase regulator activity | regulation of chemotaxis | regulation of monocyte chemotaxis | positive regulation of nitrogen compound metabolic process | granulocyte chemotaxis | regulation of cell differentiation | muscle structure development | T cell chemotaxis | regulation of myotube differentiation | regulation of angiogenesis | regulation of cellular process | cellular response to lipid | regulation of metabolic process | regulation of cytosolic calcium ion concentration | cellular response to molecule of bacterial origin | calcium ion homeostasis | regulation of vasculature development | response to stimulus | neutrophil chemotaxis | positive regulation of immune system process | negative regulation of striated muscle cell differentiation | response to cold | response to stress | positive regulation of cation transmembrane transport | positive regulation of T cell migration | regulation of cell proliferation | lymphocyte chemotaxis | negative regulation of angiogenesis | response to temperature stimulus | response to molecule of bacterial origin | endothelial cell activation | response to vitamin D | blood circulation | G-protein coupled receptor signaling pathway | positive regulation of RNA biosynthetic process | cell-cell signaling | cell chemotaxis | molecular function regulator | metal ion homeostasis | leukocyte migration | regulation of nucleic acid-templated transcription | locomotion | regulation of calcium ion transport into cytosol | response to external biotic stimulus | system development | regulation of signal transduction | positive regulation of monocyte chemotaxis | positive regulation of calcium ion transmembrane transport | multicellular organism development | cell migration | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of catalytic activity | regulation of phosphorylation | positive regulation of lymphocyte migration | regulation of gene expression | positive regulation of chemotaxis | cellular response to stress | response to lipid | cellular response to heat | regulation of endothelial tube morphogenesis | positive regulation of cellular metabolic process | defense response to virus | cellular ion homeostasis | positive regulation of ion transmembrane transport | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | lymphocyte migration | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to nutrient | negative regulation of myoblast differentiation | second-messenger-mediated signaling | regulation of release of sequestered calcium ion into cytosol | positive regulation of cell migration | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | regulation of calcium ion transmembrane transport | response to gamma radiation | cation homeostasis | negative regulation of myoblast fusion | negative regulation of myotube differentiation | regulation of leukocyte migration | response to bacterium | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | antimicrobial humoral immune response mediated by antimicrobial peptide | positive regulation of leukocyte chemotaxis | cAMP-dependent protein kinase regulator activity | humoral immune response | regulation of T cell migration | inflammatory response | cyclic-nucleotide-mediated signaling | regulation of protein metabolic process | positive regulation of signal transduction | regulation of cAMP-mediated signaling | leukocyte chemotaxis | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | regulation of signaling receptor activity | antimicrobial humoral response | receptor regulator activity | response to organic substance | cAMP-mediated signaling | regulation of kinase activity | response to mechanical stimulus | positive regulation of mononuclear cell migration | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | regulation of RNA biosynthetic process | regulation of myoblast differentiation | chemical homeostasis | receptor ligand activity | immune response | cytokine activity | regulation of sequestering of calcium ion | response to vitamin | negative regulation of syncytium formation by plasma membrane fusion | animal organ development | positive regulation of ion transport | positive regulation of leukocyte migration | positive regulation of cAMP-mediated signaling | response to heat | ion homeostasis | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | regulation of ion transmembrane transport | cell activation | regulation of lymphocyte chemotaxis | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | regulation of cell communication | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | enzyme regulator activity | positive regulation of calcium ion transport into cytosol | response to biotic stimulus | regulation of developmental process | regulation of ion transport | developmental process | regulation of muscle cell differentiation | regulation of calcium ion transport | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of vasculature development | positive regulation of nucleic acid-templated transcription | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | T cell migration | negative regulation of muscle cell differentiation | positive regulation of metabolic process | immune system process | cellular response to organic substance | positive regulation of cell motility | neutrophil migration | chemotaxis | divalent inorganic cation homeostasis | regulation of lymphocyte migration | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of calcium ion transport | response to ionizing radiation | muscle organ development | response to other organism | positive regulation of signaling | regulation of T cell chemotaxis | signal transduction | regulation of signaling | positive regulation of gene expression | response to auditory stimulus | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

cell | external side of plasma membrane | plasma membrane | extracellular region | extracellular space | cell periphery | cell surface | intracellular | membrane