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QuickView for CXCL1 (gene)


Gene Symbol:
CXCL1 Homo sapiens Homo sapiens
Full name:
C-X-C motif chemokine ligand 1
Synonyms:
FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1, growth-regulated alpha protein, C-X-C motif chemokine 1, GRO-alpha(1-73), GRO1 oncogene (melanoma growth stimulating activity, alpha), GRO1 oncogene (melanoma growth-stimulating activity), MGSA alpha, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), fibroblast secretory protein, melanoma growth stimulating activity, alpha, melanoma growth stimulatory activity alpha, neutrophil-activating protein 3
Genomic Location:
Chr 4: 74953973-74955817
Description:
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and pr...
Orthologs:
Mus musculus Rattus norvegicus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 4
4q13.3


Transcripts Names
NM_001511
NR_046035
Protein Names
P09341
Q9UCR7



GO Molecular Function

enzyme activator activity | chemokine activity | signaling receptor binding | cytokine receptor binding | molecular function regulator | chemokine receptor binding | protein binding | receptor regulator activity | growth factor activity | G-protein coupled receptor binding | receptor ligand activity | cytokine activity | enzyme regulator activity

GO Biological Process

actin filament-based process | exocytosis | response to cytokine | cell motility | neutrophil activation | response to lipopolysaccharide | intracellular signal transduction | enzyme activator activity | actin cytoskeleton organization | establishment of localization | negative regulation of cellular process | chemokine-mediated signaling pathway | defense response | nervous system development | cellular process | secretion | leukocyte degranulation | localization | chemokine activity | positive regulation of catalytic activity | granulocyte chemotaxis | regulation of cellular process | leukocyte activation | cellular response to lipid | cellular response to molecule of bacterial origin | cellular component organization | response to stimulus | neutrophil degranulation | neutrophil chemotaxis | response to stress | leukocyte activation involved in immune response | regulation of cell proliferation | secretion by cell | response to molecule of bacterial origin | G-protein coupled receptor signaling pathway | cell chemotaxis | molecular function regulator | leukocyte migration | locomotion | response to external biotic stimulus | system development | regulation of signal transduction | multicellular organism development | cell migration | leukocyte mediated immunity | regulation of catalytic activity | response to lipid | cytokine-mediated signaling pathway | vesicle-mediated transport | cellular response to cytokine stimulus | cell proliferation | regulated exocytosis | response to bacterium | cell communication | antimicrobial humoral immune response mediated by antimicrobial peptide | humoral immune response | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | leukocyte chemotaxis | positive regulation of molecular function | regulation of signaling receptor activity | antimicrobial humoral response | receptor regulator activity | response to organic substance | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | receptor ligand activity | immune response | cytokine activity | cytoskeleton organization | cell activation | regulation of cell communication | signaling | enzyme regulator activity | response to biotic stimulus | developmental process | organelle organization | negative regulation of cell proliferation | neutrophil mediated immunity | immune system process | cellular response to organic substance | neutrophil migration | chemotaxis | response to other organism | signal transduction | regulation of signaling | cellular response to lipopolysaccharide | multicellular organismal process

GO Cellular Component

secretory granule | tertiary granule | cytoplasmic vesicle | cell | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | secretory vesicle | endomembrane system | vesicle | specific granule | extracellular region | membrane-bounded organelle | specific granule lumen | organelle | extracellular space | tertiary granule lumen | membrane-enclosed lumen | secretory granule lumen | intracellular vesicle | intracellular | vesicle lumen