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QuickView for CXCR2 (gene)


Gene Symbol:
CXCR2 Homo sapiens Homo sapiens
Full name:
C-X-C motif chemokine receptor 2
Synonyms:
CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, C-X-C chemokine receptor type 2, CXC-R2, CXCR-2, CXCR2 gene for IL8 receptor type B, GRO/MGSA receptor, IL-8 receptor type 2, IL-8R B, chemokine (CXC) receptor 2, high affinity interleukin-8 receptor B, interleukin 8 receptor type 2, interleukin 8 receptor, beta, interleukin-8 receptor type B
Genomic Location:
Chr 2: 218698991-218710220
Description:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with mela...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 2
2q35





GO Molecular Function

cytokine binding | interleukin-8 binding | C-X-C chemokine binding | transmembrane signaling receptor activity | G-protein coupled receptor activity | chemokine binding | signaling receptor activity | G-protein coupled chemoattractant receptor activity | cytokine receptor activity | protein binding | interleukin-8 receptor activity | C-C chemokine receptor activity | peptide receptor activity | chemokine receptor activity | G-protein coupled peptide receptor activity | C-C chemokine binding | C-X-C chemokine receptor activity

GO Biological Process

regulation of leukocyte chemotaxis | brain development | positive regulation of locomotion | negative regulation of immune system process | exocytosis | response to cytokine | cell motility | neutrophil activation | intracellular signal transduction | positive regulation of apoptotic process | regulation of localization | cellular response to interleukin-8 | morphogenesis of an epithelium | regulation of programmed cell death | establishment of localization | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | regulation of cardiac muscle cell apoptotic process | chemokine-mediated signaling pathway | defense response | nervous system development | cellular chemical homeostasis | positive regulation of cellular component movement | cellular process | interleukin-8-mediated signaling pathway | secretion | leukocyte degranulation | regulation of cell motility | localization | cellular homeostasis | epithelial tube morphogenesis | metanephric epithelium development | regulation of chemotaxis | negative regulation of apoptotic process | positive regulation of muscle cell apoptotic process | granulocyte chemotaxis | tissue development | regulation of angiogenesis | regulation of cellular process | leukocyte activation | regulation of apoptotic process | positive regulation of neutrophil migration | regulation of cytosolic calcium ion concentration | epithelium development | calcium ion homeostasis | regulation of neutrophil chemotaxis | urogenital system development | head development | G-protein coupled receptor activity | regulation of vasculature development | response to stimulus | neutrophil degranulation | neutrophil chemotaxis | positive regulation of immune system process | negative regulation of myeloid cell apoptotic process | response to stress | leukocyte activation involved in immune response | regulation of cell proliferation | tube morphogenesis | negative regulation of neutrophil apoptotic process | inflammatory response to antigenic stimulus | secretion by cell | midbrain development | blood circulation | G-protein coupled receptor signaling pathway | dendritic cell migration | kidney development | cell chemotaxis | metal ion homeostasis | leukocyte migration | locomotion | system development | multicellular organism development | cell migration | leukocyte mediated immunity | regulation of granulocyte chemotaxis | positive regulation of chemotaxis | kidney epithelium development | cellular ion homeostasis | positive regulation of cytosolic calcium ion concentration | regulation of cell migration | dendritic cell chemotaxis | regulation of vascular permeability | cytokine-mediated signaling pathway | vesicle-mediated transport | regulation of cellular component movement | G-protein coupled chemoattractant receptor activity | second-messenger-mediated signaling | positive regulation of cell migration | cellular response to cytokine stimulus | regulated exocytosis | cation homeostasis | regulation of leukocyte migration | cytokine receptor activity | regulation of muscle cell apoptotic process | cellular cation homeostasis | cell communication | metanephros development | positive regulation of leukocyte chemotaxis | receptor internalization | inflammatory response | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | leukocyte chemotaxis | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of locomotion | renal system development | calcium-mediated signaling | acute inflammatory response to antigenic stimulus | response to organic substance | tissue morphogenesis | import into cell | positive regulation of vascular permeability | anatomical structure development | cell surface receptor signaling pathway | metabolic process | interleukin-8 receptor activity | regulation of neutrophil migration | negative regulation of programmed cell death | positive regulation of neutrophil chemotaxis | chemical homeostasis | endocytosis | positive regulation of cell death | regulation of myeloid cell apoptotic process | immune response | organic substance metabolic process | animal organ development | metanephric tubule development | positive regulation of leukocyte migration | positive regulation of programmed cell death | ion homeostasis | phospholipase C-activating G-protein coupled receptor signaling pathway | cell activation | positive regulation of cardiac muscle cell apoptotic process | C-C chemokine receptor activity | chemokine receptor activity | signaling | G-protein coupled peptide receptor activity | negative regulation of leukocyte apoptotic process | anatomical structure morphogenesis | regulation of developmental process | receptor-mediated endocytosis | metanephric tubule morphogenesis | developmental process | tube development | receptor metabolic process | cellular defense response | neutrophil mediated immunity | positive regulation of granulocyte chemotaxis | C-X-C chemokine receptor activity | cellular metal ion homeostasis | central nervous system development | acute inflammatory response | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | neutrophil migration | chemotaxis | divalent inorganic cation homeostasis | positive regulation of angiogenesis | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cytoplasmic vesicle | cell | mast cell granule | intrinsic component of membrane | external side of plasma membrane | cytoplasm | intracellular organelle | secretory granule membrane | secretory vesicle | endomembrane system | plasma membrane | vacuole | vesicle | lytic vacuole | integral component of plasma membrane | membrane-bounded organelle | organelle | vesicle membrane | lysosome | cell periphery | intracellular vesicle | cell surface | intracellular | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane