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QuickView for CYP11BL (gene)


Gene Symbol:
CYP11B2 Homo sapiens Homo sapiens
Full name:
cytochrome P450 family 11 subfamily B member 2
Synonyms:
ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo, cytochrome P450 11B2, mitochondrial, aldosterone synthase, aldosterone-synthesizing enzyme, cytochrome P-450Aldo, cytochrome P-450C18, cytochrome P450, family 11, subfamily B, polypeptide 2, cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2, mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2, steroid 11-beta-monooxygenase, steroid 11-beta/18-hydroxylase, steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
Genomic Location:
Chr 8: 143988977-143996261
Description:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to syn...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 8
8q24.3


Transcripts Names
NM_000498
Protein Names
Q16726
P19099
B0ZBE4



GO Molecular Function

cofactor binding | cation binding | steroid hydroxylase activity | iron ion binding | corticosterone 18-monooxygenase activity | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | ion binding | organic cyclic compound binding | tetrapyrrole binding | transition metal ion binding | heme binding | steroid 11-beta-monooxygenase activity | metal ion binding | heterocyclic compound binding | oxidoreductase activity

GO Biological Process

regulation of systemic arterial blood pressure by hormone | response to hormone | response to potassium ion | response to metal ion | renal water homeostasis | sterol metabolic process | cellular process | cellular response to potassium ion | response to inorganic substance | response to peptide hormone | steroid hydroxylase activity | organic cyclic compound metabolic process | cellular response to organonitrogen compound | steroid biosynthetic process | regulation of systemic arterial blood pressure mediated by a chemical signal | cellular response to metal ion | response to stimulus | positive regulation of blood pressure | corticosterone 18-monooxygenase activity | alcohol metabolic process | multicellular organismal homeostasis | response to peptide | cellular response to inorganic substance | blood circulation | cellular biosynthetic process | metal ion homeostasis | water homeostasis | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to hormone stimulus | sodium ion homeostasis | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | cellular response to peptide hormone stimulus | hormone biosynthetic process | lipid metabolic process | regulation of hormone levels | cellular response to peptide | regulation of blood pressure | regulation of systemic arterial blood pressure | small molecule metabolic process | regulation of blood volume by renal aldosterone | cellular ketone metabolic process | biosynthetic process | lipid biosynthetic process | cation homeostasis | endocrine process | potassium ion homeostasis | mineralocorticoid biosynthetic process | homeostatic process | positive regulation of systemic arterial blood pressure | drug metabolic process | cellular aldehyde metabolic process | response to organic substance | cortisol metabolic process | metabolic process | cholesterol metabolic process | regulation of body fluid levels | oxidation-reduction process | chemical homeostasis | organic substance metabolic process | C21-steroid hormone metabolic process | ion homeostasis | renal system process | steroid metabolic process | glucocorticoid metabolic process | hormone metabolic process | renal system process involved in regulation of systemic arterial blood pressure | C21-steroid hormone biosynthetic process | glucocorticoid biosynthetic process | steroid 11-beta-monooxygenase activity | multicellular organismal water homeostasis | response to organonitrogen compound | aldosterone biosynthetic process | cellular metabolic process | cellular response to organic substance | oxidoreductase activity | cortisol biosynthetic process | multicellular organismal process

GO Cellular Component

organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | mitochondrial envelope | mitochondrial membrane | intracellular | membrane