QuickView for CYP1A1%3Bjsessionid%3D5B4BAB496B1F3AAEDB44A6F2C495DE16 (gene)

Gene Symbol:

CYP1A1 Homo sapiens

Full name:

cytochrome P450 family 1 subfamily A member 1

Synonyms:

AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX, cytochrome P450 1A1, aryl hydrocarbon hydroxylase, cytochrome P1-450, dioxin-inducible, cytochrome P450 form 6, cytochrome P450, family 1, subfamily A, polypeptide 1, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, cytochrome P450-C, cytochrome P450-P1, flavoprotein-linked monooxygenase, xenobiotic monooxygenase

Genomic Location:

Chr 15: 72798943-72804930

Description:

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aro...

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This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6_01 ,  TGACCTY_ERR1_Q2 ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  CAGGTG_E12_Q6 ,  AHR_Q5 ,  AHR_01 ,  MZF1_02 ,  HNF4_01_B

miRNA binding sites
(Source: miRecords):

hsa-miR-125b Targeted Genes

Cytogenetic Map:

15q24.1

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