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QuickView for CYP1A1;jsessionid=5B4BAB496B1F3AAEDB44A6F2C495DE16 (gene)


Gene Symbol:
CYP1A1 Homo sapiens Homo sapiens
Full name:
cytochrome P450 family 1 subfamily A member 1
Synonyms:
AHH, AHRR, CP11, CYP1, CYPIA1, P1-450, P450-C, P450DX, cytochrome P450 1A1, aryl hydrocarbon hydroxylase, cytochrome P1-450, dioxin-inducible, cytochrome P450 form 6, cytochrome P450, family 1, subfamily A, polypeptide 1, cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, cytochrome P450-C, cytochrome P450-P1, flavoprotein-linked monooxygenase, xenobiotic monooxygenase
Genomic Location:
Chr 15: 72798943-72804930
Description:
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aro...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Bos taurus Gallus gallus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 15
15q24.1





GO Molecular Function

cofactor binding | vitamin D 24-hydroxylase activity | cation binding | enzyme binding | steroid hydroxylase activity | iron ion binding | demethylase activity | oxidoreductase activity, acting on diphenols and related substances as donors | catalytic activity | estrogen 16-alpha-hydroxylase activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | tetrapyrrole binding | oxygen binding | protein binding | transition metal ion binding | heme binding | drug binding | flavonoid 3'-monooxygenase activity | metal ion binding | heterocyclic compound binding | oxidoreductase activity | aromatase activity | small molecule binding

GO Biological Process

response to extracellular stimulus | regulation of cell cycle process | response to virus | response to nutrient levels | response to nematode | response to lipopolysaccharide | regulation of cell cycle G1/S phase transition | isoprenoid biosynthetic process | positive regulation of G1/S transition of mitotic cell cycle | eye development | response to immobilization stress | ethylene metabolic process | vitamin D 24-hydroxylase activity | response to metal ion | cell differentiation | response to drug | reactive oxygen species metabolic process | xenobiotic catabolic process | regulation of G1/S transition of mitotic cell cycle | response to antibiotic | hydrogen peroxide biosynthetic process | cellular process | organic substance catabolic process | toxin metabolic process | multicellular organismal reproductive process | response to hypoxia | terpenoid biosynthetic process | regulation of cell cycle | response to inorganic substance | tissue development | porphyrin-containing compound metabolic process | regulation of cellular process | parturition | regulation of metabolic process | omega-hydroxylase P450 pathway | xenobiotic metabolic process | catabolic process | steroid hydroxylase activity | retinoic acid biosynthetic process | hepaticobiliary system development | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | epithelium development | cellular aromatic compound metabolic process | cellular lipid metabolic process | cellular response to metal ion | response to stimulus | monocarboxylic acid metabolic process | regulation of mitotic cell cycle phase transition | lipid hydroxylation | cellular response to xenobiotic stimulus | response to stress | demethylase activity | regulation of cell cycle phase transition | reproduction | cellular response to inorganic substance | response to molecule of bacterial origin | cellular response to organic cyclic compound | cofactor metabolic process | reactive oxygen species biosynthetic process | amine metabolic process | oxidoreductase activity, acting on diphenols and related substances as donors | cellular biosynthetic process | response to iron ion | response to herbicide | organic hydroxy compound metabolic process | retinoid metabolic process | estrogen 16-alpha-hydroxylase activity | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | multicellular organism development | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | antibiotic metabolic process | lipid metabolic process | regulation of hormone levels | positive regulation of cell cycle | positive regulation of mitotic cell cycle | response to lipid | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | 9-cis-retinoic acid biosynthetic process | cofactor biosynthetic process | liver development | dibenzo-p-dioxin metabolic process | small molecule metabolic process | response to nutrient | fatty acid biosynthetic process | cell proliferation | biosynthetic process | long-chain fatty acid biosynthetic process | hepatocyte differentiation | response to hyperoxia | flavonoid metabolic process | digestive tract development | response to vitamin A | lipid biosynthetic process | response to toxic substance | response to xenobiotic stimulus | positive regulation of cell cycle G1/S phase transition | sensory organ development | response to bacterium | retinoic acid metabolic process | aromatic compound catabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | lipid modification | long-chain fatty acid metabolic process | response to insecticide | regulation of mitotic cell cycle | drug metabolic process | carboxylic acid metabolic process | multicellular organism reproduction | maternal process involved in parturition | response to organic substance | gland development | digestive system development | vitamin metabolic process | response to wounding | anatomical structure development | positive regulation of mitotic cell cycle phase transition | metabolic process | oxidation-reduction process | 9-cis-retinoic acid metabolic process | organic substance metabolic process | response to copper ion | response to vitamin | animal organ development | diterpenoid metabolic process | fatty acid metabolic process | response to iron(III) ion | camera-type eye development | icosanoid metabolic process | steroid metabolic process | coumarin metabolic process | response to arsenic-containing substance | response to organic cyclic compound | organic acid metabolic process | dibenzo-p-dioxin catabolic process | hormone metabolic process | epoxygenase P450 pathway | response to biotic stimulus | isoprenoid metabolic process | developmental process | positive regulation of cell cycle process | flavonoid 3'-monooxygenase activity | tube development | epithelial cell differentiation | heterocycle metabolic process | demethylation | hydrogen peroxide metabolic process | regulation of lipid metabolic process | insecticide metabolic process | cellular metabolic process | cellular response to organic substance | cellular response to copper ion | oxidoreductase activity | aromatase activity | response to food | aging | arachidonic acid metabolic process | vitamin D metabolic process | response to other organism | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | mitochondrion | membrane-bounded organelle | organelle | intracellular | membrane