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QuickView for CYP2C18 (gene)


Gene Symbol:
CYP2C18 Homo sapiens Homo sapiens
Full name:
cytochrome P450 family 2 subfamily C member 18
Synonyms:
CPCI, CYP2C, CYP2C17, P450-6B/29C, P450IIC17, cytochrome P450 2C18, (S)-mephenytoin hydroxylase associated cytochrome P450, CYPIIC18, cytochrome P450, family 2, subfamily C, polypeptide 18, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18, cytochrome P450-6B/29C, flavoprotein-linked monooxygenase, microsomal monooxygenase, unspecific monooxygenase
Genomic Location:
Chr 10: 96433368-96485514
Description:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The g...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 10
10q23.33


Transcripts Names
NM_000772
NM_001128925



GO Molecular Function

cofactor binding | cation binding | steroid hydroxylase activity | iron ion binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | arachidonic acid monooxygenase activity | tetrapyrrole binding | oxygen binding | transition metal ion binding | heme binding | drug binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | aromatase activity | small molecule binding | arachidonic acid epoxygenase activity

GO Biological Process

response to drug | cellular process | xenobiotic metabolic process | catabolic process | steroid hydroxylase activity | response to stimulus | cellular response to xenobiotic stimulus | drug catabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | small molecule metabolic process | exogenous drug catabolic process | response to xenobiotic stimulus | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | arachidonic acid monooxygenase activity | drug metabolic process | metabolic process | oxidation-reduction process | organic substance metabolic process | organic acid metabolic process | cellular metabolic process | oxidoreductase activity | aromatase activity | arachidonic acid epoxygenase activity

GO Cellular Component

intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane