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QuickView for CYP2E1 (gene)


Gene Symbol:
CYP2E1 Homo sapiens Homo sapiens
Full name:
cytochrome P450 family 2 subfamily E member 1
Synonyms:
CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 2E1, 4-nitrophenol 2-hydroxylase, CYPIIE1, cytochrome P450, family 2, subfamily E, polypeptide 1, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1, cytochrome P450-J, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
Genomic Location:
Chr 10: 135190857-135202610
Description:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 10
10q26.3


Transcripts Names
NM_000773
Protein Names
Q9UK47
Q5VZD5
P05181



GO Molecular Function

cofactor binding | cation binding | enzyme binding | steroid hydroxylase activity | iron ion binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | arachidonic acid monooxygenase activity | tetrapyrrole binding | oxygen binding | protein binding | transition metal ion binding | heme binding | drug binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding | arachidonic acid epoxygenase activity

GO Biological Process

response to drug | benzene-containing compound metabolic process | response to antibiotic | cellular process | triglyceride metabolic process | response to inorganic substance | benzene metabolic process | xenobiotic metabolic process | catabolic process | steroid hydroxylase activity | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular lipid metabolic process | response to stimulus | monocarboxylic acid metabolic process | cellular response to xenobiotic stimulus | response to stress | response to ozone | carbon tetrachloride metabolic process | response to alcohol | cellular biosynthetic process | drug catabolic process | response to ethanol | response to nitrogen compound | response to external biotic stimulus | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | small molecule metabolic process | response to oxidative stress | exogenous drug catabolic process | fatty acid biosynthetic process | biosynthetic process | long-chain fatty acid biosynthetic process | lipid biosynthetic process | response to toxic substance | response to xenobiotic stimulus | response to bacterium | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | glycerolipid metabolic process | long-chain fatty acid metabolic process | arachidonic acid monooxygenase activity | drug metabolic process | carboxylic acid metabolic process | monoterpenoid metabolic process | response to organic substance | neutral lipid metabolic process | metabolic process | oxidation-reduction process | organic substance metabolic process | response to reactive oxygen species | fatty acid metabolic process | steroid metabolic process | organic acid metabolic process | response to biotic stimulus | isoprenoid metabolic process | response to organonitrogen compound | heterocycle metabolic process | cellular metabolic process | oxidoreductase activity | acylglycerol metabolic process | halogenated hydrocarbon metabolic process | response to other organism | arachidonic acid epoxygenase activity

GO Cellular Component

intracellular membrane-bounded organelle | organelle membrane | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | mitochondrion | Golgi membrane | membrane-bounded organelle | organelle | intracellular | membrane