QuickView for CYP2E1 (gene)

Gene Symbol:

CYP2E1 Homo sapiens

Full name:

cytochrome P450 family 2 subfamily E member 1

Synonyms:

CPE1, CYP2E, P450-J, P450C2E, cytochrome P450 2E1, 4-nitrophenol 2-hydroxylase, CYPIIE1, cytochrome P450, family 2, subfamily E, polypeptide 1, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1, cytochrome P450-J, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase

Genomic Location:

Chr 10: 135190857-135202610

Description:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation...

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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF1_01 ,  RSRFC4_01 ,  RSRFC4_Q2 ,  ARP1_01 ,  CTTTGA_LEF1_Q2 ,  CTAWWWATA_RSRFC4_Q2 ,  TCF4_Q5 ,  TATAAA_TATA_01 ,  LEF1_Q2 ,  YAATNANRNNNCAG_UNKNOWN ,  HNF1_Q6

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Cytogenetic Map:

10q26.3

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