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QuickView for Carbinoxamine (compound)


PubChem
Name: carbinoxamine
PubChem Compound ID: 2564
Molecular formula: C16H19ClN2O
Molecular weight: 290.788 g/mol
Synonyms:
KBio1_000819; Allergefon; KBioGR_000728; BRN 0250475; Rotoxamine; Spectrum4_000264; Spectrum2_001127; Spectrum_000100; (+-)-Carbinoxamine; McN-R 73Z.
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DrugBank
Identification
Name: carbinoxamine
Name (isomeric): DB00748
Drug Type: small molecule
Synonyms:
Paracarinoxamine; Paracarbinoxamine; Carbinoxamine Maleate
Brand: Allergefon, Twiston, Clistin, Rotoxamine
Category: Antihistamines
CAS number: 486-16-8
Pharmacology
Indication: For symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis, as well as allergic conjunctivitis caused by foods and inhaled allergens. Also for the relief of allergic reactions to blood or plasma, and the symptomatic management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
Pharmacology:
Carbinoxamine is a first generation antihistamine of the ethanolamine class. Ethanolamine antihistamines have significant antimuscarinic activity and produce marked sedation in most patients. In addition to the usual allergic symptoms, the drug also treats irritant cough and nausea, vomiting, and vertigo associated with motion sickness. It also is ...
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Mechanism of Action:
Carbinoxamine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Carbinoxamine's anticholinergic action appears to be due to a central antimuscarinic effect, which also may be responsibl...
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Half Life: 10 to 20 hours
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
TacrineThe therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Carbinoxamine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
DonepezilPossible antagonism of action
TrimethobenzamideTrimethobenzamide and Carbinoxamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
PramlintidePramlintide may enhance the anticholinergic effect of Anticholinergics such as carbinoxamine. These effects are specific to the gastrointestinal tract. Use caution during concomitant therapy with pramlintide and anticholinergics. Additive effects on reduced gastrointestinal motility may occur.
Benzylpenicilloyl PolylysineAntihistamines may diminish the diagnostic effect of Benzylpenicilloyl Polylysine. Treatment with systemic histamine H1 antagonists such as carbinoxamine should be suspended for benzylpenicilloyl-polylysine skin testing to minimize the potential for false negative results. Delay skin testing until the systemic effects of the antihistamine have dissipated. A histamine skin test may be used to assess residual antihistaminic effects.
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Targets


Enzymes