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QuickView for Carprofen (compound)
PubChem
| Name: | carprofen |
|---|---|
| PubChem Compound ID: | 10039040 |
| Molecular formula: | C15H12ClNO2 |
| Molecular weight: | 274.72 g/mol |
DrugBank
Identification
| Name: | carprofen |
|---|---|
| Name (isomeric): | DB00821 |
| Drug Type: | small molecule |
| Synonyms: |
Carprofenum [inn-latin]; 6-Chloro-alpha-methylcarbazole-2-acetic acid; 2-(6-Chloro-9H-carbazol-2-yl)propanoic acid; 6-Chloro-alpha-methyl-9H-carbazole-2-acetic acid; Carprofeno [inn-spanish]; Carprofene [inn-french]
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| Brand: | Rimadyl, Ridamyl |
| Category: | Photosensitizing Agents |
| CAS number: | 53716-49-7 |
Pharmacology
| Indication: | For use as a pain reliever in the treatment of joint pain and post-surgical pain. |
|---|---|
| Pharmacology: |
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen, naproxen, and ketoprofen. It is no longer used in the clinical setting, but is approved for use in dogs. Carprofen is non-narcotic and has characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in anim...
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| Mechanism of Action: |
The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxyge...
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| Absorption: | Rapidly and nearly completely absorbed (more than 90% bioavailable) when administered orally. |
| Protein binding: | High (99%) |
| Biotransformation: | Hepatic. |
| Half Life: | Approximately 8 hours (range 4.5–9.8 hours) in dogs. |
| Toxicity: | Symptoms of NSAID overdose include dizziness and nystagmus. Oral LD50 in mouse and rat is 282 mg/kg and 149 mg/kg, respectively. |
| Affected organisms: | Humans and other mammals |
Targets
Transporters
