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QuickView for Caspofungin (compound)

Name: caspofungin
PubChem Compound ID: 11954244
Molecular formula: C56H96N10O19
Molecular weight: 1213.42 g/mol
Cancidas; D02501; Cancidas (TN); Caspofungin acetate; Caspofungin acetate (USAN); 179463-17-3
Name: caspofungin
Name (isomeric): DB00520
Drug Type: small molecule
Capsofungin; Caspofungin acetate
Brand: Cancidas
Category: Antifungal Agents, Antifungals
CAS number: 179463-17-3
Indication: For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Caspofungin is an antifungal drug, and belongs to a new class termed the echinocandins. It is used to treat Aspergillus and Candida infection, and works by inhibiting cell wall synthesis. Antifungals in the echinocandin class inhibit the synthesis of glucan in the cell wall, probably via the enzyme 1,3-beta glucan synthase. There is a...
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Mechanism of Action: Caspofungin inhibits the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species. beta-(1,3)-D-glucan is not present in mammalian cells. The primary target is beta-(1,3)-glucan synthase.
Absorption: 92% tissue distribution within 36-48 hours after intravenous infusion
Protein binding: 97%
Biotransformation: Metabolized slowly by hydrolysis and N-acetylation
Route of elimination: After single intravenous administration of [3H] caspofungin acetate, excretion of caspofungin and its metabolites in humans was 35% of dose in feces and 41% of dose in urine.
Half Life: 9-11 hours
Clearance: 12 mL/min [After single IV administration]
Toxicity: Side effects include rash, swelling, and nausea (rare)
Affected organisms: Aspergillis, Candida and other fungi
Drug interaction:
TacrolimusCaspofungin may decrease the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Caspofungin therapy is initiated, discontinued or altered.
CyclosporineCyclosporine increases the effect and toxicity of caspofungin
RifampinDecreased levels/effects of caspofungin