QuickView for Cav1 (gene)
- Gene Symbol:
- CAV1
Homo sapiens - Full name:
- caveolin 1
- Synonyms:
- BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21, caveolin-1, caveolin 1, caveolae protein, 22kDa, cell growth-inhibiting protein 32
- Genomic Location:
- Chr 7: 115952075-115988466
- Description:
-
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negati...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-142-5p , Predicted Gene Targets for miR-199 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-204 , Predicted Gene Targets for miR-30-3p , Predicted Gene Targets for miR-431 , Predicted Gene Targets for miR-96 , Predicted Gene Targets for miR-124a , Predicted Gene Targets for miR-505
- miRNA binding sites
(Source: miRecords):
- Cytogenetic Map:
-
7q31.2
GO Molecular Function
structural molecule activity | kinase binding | enzyme activator activity | GTPase binding | Rho GTPase binding | patched binding | channel regulator activity | protein kinase binding | enzyme binding | lipid binding | peptidase activator activity | sterol binding | potassium channel inhibitor activity | ion channel inhibitor activity | signaling receptor binding | inward rectifier potassium channel inhibitor activity | alcohol binding | Ras GTPase binding | molecular function regulator | ion channel binding | channel inhibitor activity | protein binding, bridging | ATPase binding | identical protein binding | protein heterodimerization activity | potassium channel regulator activity | organic cyclic compound binding | cholesterol binding | molecular adaptor activity | protein binding | protein dimerization activity | Rac GTPase binding | nitric-oxide synthase binding | protein-containing complex scaffold activity | small GTPase binding | enzyme regulator activity | steroid binding | small molecule binding
GO Biological Process
positive regulation of immune response | negative regulation of phosphorylation | cellular response to increased oxygen levels | protein homooligomerization | regulation of blood vessel diameter | regulation of muscle system process | positive regulation of locomotion | heart process | negative regulation of MAPK cascade | positive regulation of blood circulation | positive regulation of cellular component organization | cell motility | protein localization to cell periphery | regulation of cellular localization | muscle tissue development | enzyme activator activity | positive regulation of apoptotic process | receptor-mediated endocytosis of virus by host cell | regulation of localization | regulation of the force of heart contraction by chemical signal | protein localization to basolateral plasma membrane | lipid transport | regulation of programmed cell death | protein localization to membrane raft | establishment of localization | regulation of immune system process | response to hormone | negative regulation of potassium ion transport | cellular response to hyperoxia | lipid storage | regulation of nitric oxide biosynthetic process | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | negative regulation of kinase activity | regulation of MAP kinase activity | negative regulation of RNA biosynthetic process | response to metal ion | positive regulation of lymphocyte activation | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of intrinsic apoptotic signaling pathway | regulation of toll-like receptor 3 signaling pathway | regulation of smooth muscle contraction | positive regulation of protein catabolic process | response to drug | lymphocyte costimulation | negative regulation of protein phosphorylation | cellular chemical homeostasis | regulation of cell communication by electrical coupling involved in cardiac conduction | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | membrane organization | regulation of ventricular cardiac muscle cell action potential | membrane biogenesis | blood vessel morphogenesis | regulation of necroptotic process | cellular process | secretion | response to exogenous dsRNA | regulation of necrotic cell death | channel regulator activity | regulation of cell motility | localization | cellular homeostasis | tissue remodeling | negative regulation of signaling | metal ion transport | positive regulation of peptidyl-serine phosphorylation | negative regulation of peptidyl-serine phosphorylation | response to progesterone | canonical Wnt signaling pathway | beta-catenin destruction complex disassembly | negative regulation of anoikis | triglyceride metabolic process | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of response to cytokine stimulus | negative regulation of apoptotic process | endomembrane system organization | response to hypoxia | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | regulation of tyrosine phosphorylation of STAT protein | positive regulation of nitrogen compound metabolic process | response to inorganic substance | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of binding | regulation of cell differentiation | interspecies interaction between organisms | muscle structure development | positive regulation of vasoconstriction | caveolin-mediated endocytosis | skeletal muscle organ development | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | regulation of cytosolic calcium ion concentration | inactivation of MAPK activity | peptidase activator activity | positive regulation of cellular protein metabolic process | negative regulation of protein autophosphorylation | cellular response to organonitrogen compound | cellular component organization | entry into host cell | cellular lipid metabolic process | viral life cycle | calcium ion homeostasis | response to transforming growth factor beta | positive regulation of protein binding | mammary gland morphogenesis | positive regulation of cellular protein catabolic process | response to stimulus | vasculature development | membrane raft assembly | positive regulation of cold-induced thermogenesis | positive regulation of innate immune response | potassium channel inhibitor activity | ion channel inhibitor activity | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | regulation of cellular protein catabolic process | regulation of blood vessel size | gland morphogenesis | negative regulation of JAK-STAT cascade | response to stress | negative regulation of protein kinase activity | regulation of response to endoplasmic reticulum stress | skeletal muscle tissue development | posttranscriptional regulation of gene expression | regulation of cell proliferation | regulation of protein ubiquitination | sterol homeostasis | positive regulation of gap junction assembly | tube morphogenesis | regulation of blood circulation | regulation of cardiac muscle cell contraction | response to peptide | positive regulation of cell-cell adhesion | cholesterol homeostasis | regulation of epithelial cell differentiation | programmed cell death | positive regulation of proteolysis involved in cellular protein catabolic process | positive regulation of cell activation | regulation of heart rate | negative regulation of transporter activity | cellular localization | divalent metal ion transport | negative regulation of tyrosine phosphorylation of STAT protein | organic hydroxy compound transport | cardiovascular system development | positive regulation of ER-associated ubiquitin-dependent protein catabolic process | positive regulation of proteolysis | negative regulation of necroptotic process | response to ischemia | positive regulation of T cell activation | inward rectifier potassium channel inhibitor activity | negative regulation of transport | cellular response to organic cyclic compound | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | cellular component assembly | regulation of wound healing | regulation of anoikis | negative regulation of potassium ion transmembrane transport | negative regulation of nitric oxide biosynthetic process | membrane raft organization | regulation of cell adhesion | negative regulation of reactive oxygen species biosynthetic process | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | negative regulation of transmembrane transport | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | blood vessel development | leukocyte migration | negative regulation of blood vessel diameter | regulation of nucleic acid-templated transcription | regulation of potassium ion transmembrane transport | negative regulation of cellular response to transforming growth factor beta stimulus | regulation of membrane potential | regulation of cellular response to stress | regulation of neurotransmitter levels | locomotion | response to nitrogen compound | apoptotic process | regulation of calcium ion transport into cytosol | cellular response to hormone stimulus | regulation of cell projection assembly | regulation of protein tyrosine kinase activity | positive regulation of cell junction assembly | response to external biotic stimulus | system development | response to oxygen levels | regulation of signal transduction | Wnt signaling pathway | negative regulation of phosphate metabolic process | channel inhibitor activity | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of toll-like receptor signaling pathway | cellular response to peptide hormone stimulus | regulation of peptidase activity | regulation of MAPK cascade | response to dsRNA | mammary gland development | protein complex oligomerization | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | plasma membrane organization | regulation of nitric-oxide synthase activity | positive regulation of cell adhesion molecule production | regulation of T cell activation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | viral entry into host cell | negative regulation of peptidyl-tyrosine autophosphorylation | protein localization to membrane | organic substance transport | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | membrane assembly | regulation of protein autophosphorylation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | animal organ morphogenesis | cellular response to exogenous dsRNA | regulation of blood coagulation | cellular response to oxygen levels | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cell migration | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | regulation of the force of heart contraction | negative regulation of binding | positive regulation of hydrolase activity | regulation of fatty acid metabolic process | mammary gland involution | positive regulation of cell migration | negative regulation of ion transmembrane transport | sterol transport | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | vasoconstriction | angiogenesis | response to hyperoxia | negative regulation of ion transport | potassium channel regulator activity | cholesterol transport | regulation of apoptotic signaling pathway | regulation of heart contraction | cation homeostasis | cellular response to angiotensin | regulation of potassium ion transmembrane transporter activity | regulation of striated muscle contraction | maintenance of protein location | response to bacterium | response to estrogen | angiotensin-activated signaling pathway | striated muscle tissue development | cellular cation homeostasis | positive regulation of extrinsic apoptotic signaling pathway | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein kinase activity | negative regulation of cation channel activity | receptor internalization | negative regulation of necrotic cell death | regulation of cardiac muscle contraction | regulation of entry of bacterium into host cell | regulation of ER-associated ubiquitin-dependent protein catabolic process | regulation of cardiac muscle cell action potential | regulation of protein metabolic process | positive regulation of signal transduction | vasculogenesis | cellular calcium ion homeostasis | cellular response to dsRNA | homeostatic process | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of locomotion | glycerolipid metabolic process | negative regulation of MAP kinase activity | regulation of RNA metabolic process | negative regulation of protein ubiquitination | regulation of tube size | positive regulation of transport | viral process | regulation of cellular response to growth factor stimulus | apoptotic signaling pathway | negative regulation of epithelial cell differentiation | regulation of potassium ion transport | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | cellular response to transforming growth factor beta stimulus | negative regulation of monooxygenase activity | response to angiotensin | protein-containing complex assembly | positive regulation of toll-like receptor 3 signaling pathway | negative regulation of epithelial cell proliferation | regulation of heart rate by cardiac conduction | negative regulation of transforming growth factor beta receptor signaling pathway | positive regulation of protein modification process | response to organic substance | gland development | regulation of innate immune response | neutral lipid metabolic process | regulation of inward rectifier potassium channel activity | regulation of JAK-STAT cascade | lactation | regulation of kinase activity | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | negative regulation of response to cytokine stimulus | regulation of vasoconstriction | negative regulation of endocytosis | metabolic process | lipid localization | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of body fluid levels | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | regulation of tube diameter | cellular protein localization | regulation of vesicle-mediated transport | negative regulation of endothelial cell proliferation | chemical homeostasis | calcium ion transport | endocytosis | positive regulation of cell death | body fluid secretion | membrane depolarization | regulation of ruffle assembly | G-protein coupled receptor signaling pathway involved in heart process | negative regulation of pinocytosis | positive regulation of cellular component biogenesis | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | cell death | regulation of cell communication by electrical coupling | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of ERAD pathway | animal organ development | positive regulation of ion transport | regulation of endothelial cell proliferation | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of programmed cell death | caveola assembly | ion homeostasis | maintenance of protein location in cell | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | negative regulation of potassium ion transmembrane transporter activity | regulation of ion transmembrane transport | positive regulation of binding | vesicle organization | regulation of reactive oxygen species biosynthetic process | positive regulation of canonical Wnt signaling pathway | regulation of peptidyl-serine phosphorylation | anatomical structure formation involved in morphogenesis | protein localization to plasma membrane raft | negative regulation of protein metabolic process | regulation of action potential | T cell costimulation | regulation of response to wounding | regulation of cell communication | receptor internalization involved in canonical Wnt signaling pathway | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | regulation of protein binding | response to organic cyclic compound | nitric oxide homeostasis | regulation of endocytosis | negative regulation of peptidyl-tyrosine phosphorylation | regulation of transmembrane transporter activity | protein localization | regulation of epithelial cell proliferation | protein-containing complex disassembly | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | enzyme regulator activity | anatomical structure morphogenesis | positive regulation of ERAD pathway | cation transport | cellular macromolecule localization | positive regulation of calcium ion transport into cytosol | response to biotic stimulus | negative regulation of voltage-gated potassium channel activity | regulation of cellular ketone metabolic process | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | developmental process | negative regulation of canonical Wnt signaling pathway | organelle organization | negative regulation of nitric-oxide synthase activity | regulation of cardiac conduction | regulation of calcium ion transport | negative regulation of transcription by RNA polymerase II | tube development | regulation of cell junction assembly | regulation of transport | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | negative regulation of oxidoreductase activity | receptor metabolic process | regulation of cation channel activity | response to organonitrogen compound | plasma membrane raft assembly | cellular metal ion homeostasis | negative regulation of cytokine-mediated signaling pathway | regulation of membrane repolarization during action potential | response to calcium ion | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of actin filament-based process | negative regulation of Wnt signaling pathway | ion transport | regulation of cell projection organization | immune system process | positive regulation of Wnt signaling pathway | cellular metabolic process | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | response to steroid hormone | negative regulation of protein tyrosine kinase activity | negative regulation of cell death | acylglycerol metabolic process | circulatory system development | regulation of ubiquitin-dependent protein catabolic process | negative regulation of inward rectifier potassium channel activity | divalent inorganic cation homeostasis | positive regulation of leukocyte cell-cell adhesion | positive regulation of protein ubiquitination | lipid homeostasis | regulation of membrane repolarization | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of calcium ion transport | positive regulation of apoptotic signaling pathway | muscle organ development | positive regulation of toll-like receptor signaling pathway | response to other organism | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | regulation of cardiac muscle cell action potential involved in regulation of contraction | signal transduction | regulation of signaling | cardiac conduction | angiotensin-activated signaling pathway involved in heart process | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | positive regulation of response to endoplasmic reticulum stress | maintenance of location in cell | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | integral component of membrane | intracellular membrane-bounded organelle | early endosome membrane | sarcolemma | endocytic vesicle membrane | adherens junction | organelle membrane | focal adhesion | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | cell-substrate junction | acrosomal vesicle | intracellular organelle | endoplasmic reticulum | membrane microdomain | secretory granule membrane | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | secretory vesicle | endomembrane system | endoplasmic reticulum membrane | plasma membrane | cilium | membrane raft | vesicle | lipid droplet | perinuclear region of cytoplasm | cytoplasmic region | acrosomal membrane | integral component of plasma membrane | Golgi membrane | endosome | cell cortex | membrane-bounded organelle | organelle | vesicle membrane | VCP-NPL4-UFD1 AAA ATPase complex | cell periphery | early endosome | cell-substrate adherens junction | plasma membrane raft | intracellular vesicle | endocytic vesicle | intracellular | cell junction | caveola | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane
