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QuickView for Cdc42Hs (gene)


Gene Symbol:
CDC42 Homo sapiens Homo sapiens
Full name:
cell division cycle 42
Synonyms:
CDC42Hs, G25K, TKS, cell division control protein 42 homolog, G25K GTP-binding protein, GTP binding protein, 25kDa, dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)), dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)), growth-regulating protein, small GTP binding protein CDC42
Genomic Location:
Chr 1: 22251707-22292023
Description:
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The p...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Gallus gallus Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 1
1p36.12





GO Molecular Function

kinase binding | guanyl ribonucleotide binding | ribonucleoside binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | hydrolase activity | GTP-dependent protein binding | carbohydrate derivative binding | protein serine/threonine kinase activity | pyrophosphatase activity | catalytic activity | apolipoprotein A-I receptor binding | protein domain specific binding | ubiquitin-like protein transferase activity | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | identical protein binding | ubiquitin protein ligase activity | Rho GDP-dissociation inhibitor binding | thioesterase binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | GBD domain binding | apolipoprotein receptor binding | purine ribonucleoside triphosphate binding | GDP-dissociation inhibitor binding | mitogen-activated protein kinase kinase kinase binding | protein binding | transferase activity, transferring phosphorus-containing groups | ubiquitin-protein transferase activity | GTP binding | phosphotransferase activity, alcohol group as acceptor | hydrolase activity, acting on acid anhydrides | protein kinase activity | transferase activity | ubiquitin-like protein ligase activity | nucleoside binding | purine ribonucleotide binding | kinase activity | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding

GO Biological Process

positive regulation of immune response | brain development | regulation of supramolecular fiber organization | molting cycle | cell morphogenesis | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | heart process | dendritic spine development | actin filament-based process | microtubule-based transport | epidermis morphogenesis | response to cytokine | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | positive regulation of filopodium assembly | ectodermal placode formation | neuron projection morphogenesis | immune response-regulating signaling pathway | regulation of cellular localization | muscle tissue development | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | phagocytosis, engulfment | regulation of localization | actin filament bundle organization | morphogenesis of an epithelium | regulation of programmed cell death | actin cytoskeleton organization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | myeloid cell differentiation | regulation of cell shape | negative regulation of cellular process | integrin-mediated signaling pathway | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | positive regulation of epithelial cell proliferation | defense response | nervous system development | lymphocyte costimulation | multicellular organism growth | hair follicle placode formation | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of hair follicle cell proliferation | regulation of DNA replication | regulation of organelle organization | establishment or maintenance of apical/basal cell polarity | generation of neurons | membrane organization | salivary gland morphogenesis | intracellular transport | actin filament branching | microtubule-based process | blood vessel morphogenesis | regulation of neuron death | positive regulation of phosphatidylinositol 3-kinase activity | regulation of attachment of spindle microtubules to kinetochore | regulation of chromosome segregation | positive regulation of cellular biosynthetic process | cellular process | regulation of epithelial cell proliferation involved in lung morphogenesis | Fc-gamma receptor signaling pathway involved in phagocytosis | establishment of organelle localization | localization | cell projection morphogenesis | negative regulation of signaling | developmental growth | positive regulation of peptidyl-serine phosphorylation | neuron development | canonical Wnt signaling pathway | dendritic spine organization | regulation of mitotic nuclear division | immune system development | macromolecule localization | hemostasis | endomembrane system organization | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | establishment of localization in cell | tissue development | regulation of binding | regulation of cell differentiation | interspecies interaction between organisms | positive regulation of muscle cell differentiation | cell junction assembly | positive regulation of cytokinesis | cytoskeleton-dependent intracellular transport | positive regulation of lamellipodium assembly | morphogenesis of a polarized epithelium | regulation of immune response | regulation of cellular process | positive regulation of lamellipodium organization | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | regulation of protein complex assembly | organelle localization | Golgi localization | polarized epithelial cell differentiation | heart contraction | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | epithelium development | regulation of establishment of planar polarity | ephrin receptor signaling pathway | negative regulation of epidermal growth factor receptor signaling pathway | establishment of cell polarity | cellular component organization | viral life cycle | regulation of cell division | cellular response to interferon-gamma | head development | sprouting angiogenesis | modification of synaptic structure | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | vasculature development | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | positive regulation of immune system process | positive regulation of protein metabolic process | gland morphogenesis | response to stress | organelle transport along microtubule | positive regulation of cellular protein localization | regulation of cell proliferation | positive regulation of actin filament bundle assembly | tube morphogenesis | cardiac muscle tissue development | positive regulation of cell-cell adhesion | epithelial cell development | protein serine/threonine kinase activity | supramolecular fiber organization | positive regulation of cell activation | microtubule-based movement | cellular localization | cardiovascular system development | midbrain development | macrophage differentiation | positive regulation of T cell activation | immune response-activating signal transduction | regulation of protein transport | blood circulation | negative regulation of metabolic process | dendritic cell migration | hemopoiesis | cellular component assembly | protein modification process | regulation of actin cytoskeleton reorganization | regulation of synapse structure or activity | regulation of peptide transport | regulation of cell adhesion | response to interleukin-12 | Wnt signaling pathway, planar cell polarity pathway | interleukin-12-mediated signaling pathway | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | cell-cell signaling | regulation of intracellular transport | cell surface receptor signaling pathway involved in cell-cell signaling | Cdc42 protein signal transduction | blood vessel development | positive regulation of stress fiber assembly | leukocyte migration | neuron fate commitment | blood coagulation | leukocyte differentiation | regulation of cellular response to stress | locomotion | regulation of cell projection assembly | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | Wnt signaling pathway | regulation of protein stability | adherens junction organization | regulation of actin cytoskeleton organization | multicellular organism development | cell migration | positive regulation of DNA replication | regulation of MAPK cascade | phosphorus metabolic process | regulation of actin filament organization | actin filament organization | regulation of catalytic activity | regulation of actomyosin structure organization | regulation of phosphorylation | hair follicle morphogenesis | wound healing | Fc-gamma receptor signaling pathway | regulation of T cell activation | positive regulation of cell cycle | regulation of small GTPase mediated signal transduction | regulation of gene expression | positive regulation of intracellular protein transport | myeloid leukocyte differentiation | cell projection assembly | viral genome replication | positive regulation of cellular metabolic process | positive regulation of actin cytoskeleton reorganization | positive regulation of protein phosphorylation | ectodermal placode development | epithelial-mesenchymal cell signaling | regulation of lymphocyte activation | animal organ morphogenesis | cardiac conduction system development | regulation of synapse organization | keratinocyte development | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cell-substrate adhesion | positive regulation of synapse structural plasticity | enzyme linked receptor protein signaling pathway | positive regulation of JNK cascade | positive regulation of cell projection organization | cytokine-mediated signaling pathway | establishment or maintenance of monopolar cell polarity | positive regulation of intracellular signal transduction | vesicle-mediated transport | substantia nigra development | actin filament bundle assembly | ubiquitin protein ligase activity | synapse organization | positive regulation of cell differentiation | non-canonical Wnt signaling pathway | epidermal cell differentiation | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | angiogenesis | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | positive regulation of neuron death | epidermis development | keratinization | skin development | protein phosphorylation | cell morphogenesis involved in differentiation | positive regulation of pseudopodium assembly | keratinocyte differentiation | establishment or maintenance of cell polarity | phosphate-containing compound metabolic process | regulation of lipid kinase activity | nuclear migration | striated muscle tissue development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of cytokinesis | regulation of synapse structural plasticity | regulation of neuron apoptotic process | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | heart development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | positive regulation of transport | regulation of phospholipid metabolic process | viral process | regulation of filopodium assembly | coagulation | regulation of mitotic cell cycle | positive regulation of molecular function | nucleus localization | neuron differentiation | activation of immune response | regulation of cell morphogenesis involved in differentiation | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | hair cycle | response to organic substance | gland development | protein ubiquitination | tissue morphogenesis | Rho protein signal transduction | Golgi organization | regulation of kinase activity | response to wounding | regulation of animal organ morphogenesis | import into cell | regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | anatomical structure development | regulation of protein heterodimerization activity | cell surface receptor signaling pathway | submandibular salivary gland formation | cell projection organization | metabolic process | positive regulation of cell development | cell fate commitment | positive regulation of supramolecular fiber organization | ubiquitin-protein transferase activity | regulation of protein catabolic process | positive regulation of leukocyte activation | establishment or maintenance of epithelial cell apical/basal polarity | regulation of body fluid levels | transport along microtubule | cellular protein localization | membrane invagination | hair cycle process | endocytosis | positive regulation of cell death | cell adhesion | immune response | establishment of monopolar cell polarity | negative regulation of ERBB signaling pathway | protein kinase activity | dendritic spine morphogenesis | neuron projection development | negative regulation of protein complex assembly | filopodium assembly | positive regulation of cellular component biogenesis | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | negative regulation of gene expression | animal organ development | positive regulation of cell-substrate adhesion | establishment of epithelial cell polarity | regulation of cell activation | epithelial cell-cell adhesion | positive regulation of programmed cell death | positive regulation of kinase activity | protein modification by small protein conjugation or removal | skin epidermis development | regulation of phosphate metabolic process | cytoskeleton organization | cell-cell adhesion | response to interferon-gamma | positive regulation of intracellular transport | regulation of JNK cascade | regulation of hair follicle cell proliferation | positive regulation of MAPK cascade | positive regulation of protein transport | regulation of peptidyl-serine phosphorylation | dendrite morphogenesis | anatomical structure formation involved in morphogenesis | regulation of stress fiber assembly | establishment of apical/basal cell polarity | T cell costimulation | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | signaling | positive regulation of growth | regulation of protein binding | cell development | regulation of ERBB signaling pathway | neuron fate determination | protein localization | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule localization | regulation of actin filament bundle assembly | positive regulation of plasma membrane bounded cell projection assembly | dendrite development | regulation of developmental process | regulation of pseudopodium assembly | positive regulation of DNA metabolic process | kinase activity | developmental process | organelle organization | regulation of muscle cell differentiation | Fc receptor signaling pathway | positive regulation of cell cycle process | regulation of cell growth | cellular protein modification process | vascular endothelial growth factor receptor signaling pathway | Fc receptor mediated stimulatory signaling pathway | tube development | regulation of transport | regulation of cell-cell adhesion | innate immune response | Ras protein signal transduction | cell fate determination | regulation of lamellipodium assembly | positive regulation of lipid kinase activity | epithelial cell differentiation | establishment of Golgi localization | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of actin filament-based process | positive regulation of lipid metabolic process | regulation of cell projection organization | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | exocrine system development | regulation of cell death | regulation of substrate adhesion-dependent cell spreading | salivary gland development | establishment of epithelial cell apical/basal polarity | positive regulation of cell morphogenesis involved in differentiation | neuropilin signaling pathway | circulatory system development | phagocytosis | positive regulation of leukocyte cell-cell adhesion | positive regulation of substrate adhesion-dependent cell spreading | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of signaling | neural nucleus development | hair follicle development | positive regulation of epithelial cell proliferation involved in lung morphogenesis | signal transduction | regulation of signaling | viral RNA genome replication | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | dendritic spine | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | adherens junction | organelle membrane | microtubule organizing center | focal adhesion | cytoplasmic vesicle | cell body | actin-based cell projection | cell | neuronal cell body | ribonucleoprotein granule | Golgi transport complex | tethering complex | cytoplasm | spindle | cell-substrate junction | intracellular organelle | endoplasmic reticulum | dendritic tree | leading edge membrane | apical part of cell | centrosome | cell-cell junction | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | secretory vesicle | endomembrane system | neuron spine | endoplasmic reticulum membrane | postsynapse | plasma membrane | midbody | cell leading edge | vacuole | ribonucleoprotein complex | vesicle | extracellular exosome | microtubule cytoskeleton | cytoplasmic region | spindle midzone | Golgi membrane | extracellular region | cell cortex | membrane-bounded organelle | extracellular vesicle | filopodium | organelle | cytoplasmic ribonucleoprotein granule | extracellular space | cell periphery | cell-substrate adherens junction | cytosol | storage vacuole | intracellular vesicle | cytoskeleton | endocytic vesicle | intracellular | cell junction | myelin sheath | mitotic spindle | membrane | phagocytic vesicle