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QuickView for Cdk9 (gene)


Gene Symbol:
CDK9 Homo sapiens Homo sapiens
Full name:
cyclin dependent kinase 9
Synonyms:
C-2k, CDC2L4, CTK1, PITALRE, TAK, cyclin-dependent kinase 9, CDC2-related kinase, cell division cycle 2-like protein kinase 4, cell division protein kinase 9, serine/threonine protein kinase PITALRE, tat-associated kinase complex catalytic subunit
Genomic Location:
Chr 9: 129588152-129592184
Description:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation f...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 9
9q34.11


Transcripts Names
NM_001261
XR_002956743



GO Molecular Function

sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | cyclin binding | 7SK snRNA binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | cyclin-dependent protein kinase activity | transcription coactivator binding | carbohydrate derivative binding | protein serine/threonine kinase activity | RNA polymerase II CTD heptapeptide repeat kinase activity | catalytic activity | chromatin binding | ATP binding | anion binding | adenyl nucleotide binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | purine ribonucleoside triphosphate binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcription factor binding | snRNA binding | cyclin-dependent protein serine/threonine kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | RNA polymerase II regulatory region sequence-specific DNA binding | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | transcription cofactor binding | heterocyclic compound binding | small molecule binding | RNA binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | DNA-templated transcription, initiation | regulation of muscle system process | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | snRNA metabolic process | response to cytokine | positive regulation of cellular component organization | negative regulation of cellular process | regulation of histone H2B ubiquitination | regulation of mRNA polyadenylation | response to drug | positive regulation of phosphate metabolic process | regulation of organelle organization | regulation of DNA repair | regulation of mRNA processing | positive regulation of cellular biosynthetic process | cellular process | positive regulation of RNA binding | DNA-dependent DNA replication maintenance of fidelity | regulation of histone modification | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | snRNA transcription | negative regulation of cell cycle arrest | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | response to stimulus | cyclin-dependent protein kinase activity | positive regulation of protein metabolic process | response to stress | cellular nitrogen compound biosynthetic process | regulation of protein ubiquitination | snRNA transcription by RNA polymerase II | protein serine/threonine kinase activity | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | RNA polymerase II CTD heptapeptide repeat kinase activity | cellular biosynthetic process | macromolecule modification | negative regulation of mRNA polyadenylation | DNA repair | regulation of histone ubiquitination | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | regulation of histone phosphorylation | nitrogen compound metabolic process | positive regulation of organelle organization | replication fork processing | positive regulation of viral process | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of phosphorylation | ncRNA transcription | positive regulation of chromosome organization | positive regulation of cell cycle | regulation of gene expression | cellular response to stress | regulation of cell cycle arrest | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of mRNA 3'-end processing | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | cellular response to cytokine stimulus | phosphorylation of RNA polymerase II C-terminal domain | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | regulation of transcription elongation from RNA polymerase II promoter | phosphorylation | positive regulation of mRNA binding | positive regulation of histone H2B ubiquitination | negative regulation of mRNA processing | negative regulation of mRNA 3'-end processing | transcription elongation from RNA polymerase II promoter | protein phosphorylation | phosphate-containing compound metabolic process | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of viral process | regulation of mitotic cell cycle | positive regulation of molecular function | protein metabolic process | regulation of cardiac muscle hypertrophy | positive regulation of protein modification process | response to organic substance | regulation of mRNA binding | DNA metabolic process | positive regulation of viral transcription | cyclin-dependent protein serine/threonine kinase activity | metabolic process | positive regulation of transcription elongation from RNA polymerase II promoter | regulation of RNA biosynthetic process | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | protein kinase activity | positive regulation of mRNA 3'-UTR binding | organic substance metabolic process | negative regulation of gene expression | positive regulation of histone modification | gene expression | regulation of phosphate metabolic process | regulation of chromosome organization | positive regulation of binding | transcription initiation from RNA polymerase II promoter | regulation of DNA-templated transcription, elongation | transcription, DNA-templated | positive regulation of histone ubiquitination | negative regulation of cell cycle | regulation of transcription, DNA-templated | positive regulation of phosphorylation | cellular protein metabolic process | cellular macromolecule biosynthetic process | regulation of developmental process | kinase activity | positive regulation of DNA-templated transcription, elongation | regulation of muscle cell differentiation | cellular protein modification process | positive regulation of transcription, DNA-templated | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of viral transcription | positive regulation of metabolic process | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | DNA replication | positive regulation of histone phosphorylation | positive regulation of protein ubiquitination | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process | DNA-templated transcription, elongation | regulation of chromatin organization | regulation of phosphorus metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | catalytic complex | transcription elongation factor complex | protein kinase complex | cell | nuclear lumen | ribonucleoprotein granule | cyclin/CDK positive transcription elongation factor complex | cytoplasm | intracellular organelle | nuclear body | carboxy-terminal domain protein kinase complex | protein-containing complex | PML body | nucleoplasm | chromatin | nuclear chromosome | nuclear cyclin-dependent protein kinase holoenzyme complex | ribonucleoprotein complex | transferase complex | serine/threonine protein kinase complex | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | membrane-enclosed lumen | cyclin-dependent protein kinase holoenzyme complex | nuclear chromatin | intracellular | membrane