Name: | Cefaclor |
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PubChem Compound ID: | 2609 |
Description: | Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN. |
Molecular formula: | C15H14ClN3O4S |
Molecular weight: | 367.808 g/mol |
Synonyms: |
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-chloro-8-oxo-, [6R-[6.alpha.,7.beta.(R*)]]-; CCL
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Name: | Cefaclor |
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Name (isomeric): | DB00833 |
Drug Type: | small molecule |
Description: | Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN. |
Synonyms: |
Cephaclor; Cefaclorum [INN-Latin]; CCL; Cefaclor anhydrous
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Brand: | Alfatil, Ceclor CD, Alenfral, Raniclor, Panacef, Distaclor, Kefral, Alfacet, Ceclor, Panoral |
Category: | Cephalosporins, Anti-Bacterial Agents |
CAS number: | 53994-73-3 |
Indication: | For the treatment of certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections. |
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Pharmacology: |
Cefaclor is a second generation cephalosporin antibiotic with a spectrum resembling first-generation cephalosporins. In vitro tests demonstrate that the bactericidal action of the cephalosporins results from inhibition of cell-wall synthesis. Cefaclor has been shown to be active against most strains of the following microorganisms, both in v...
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Mechanism of Action: |
Cefaclor, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that cefaclor in...
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Absorption: | Well absorbed after oral administration, independent of food intake. |
Protein binding: | 23.5% |
Biotransformation: | No appreciable biotransformation in liver (approximately 60% to 85% of the drug is excreted unchanged in the urine within 8 hours). |
Route of elimination: | Approximately 60% to 85% of the drug is excreted unchanged in the urine within 8 hours, the greater portion being excreted within the first 2 hours. |
Half Life: | 0.6-0.9 hour |
Toxicity: | Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting. |
Affected organisms: | Enteric bacteria and other eubacteria |
Food interaction: |
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Drug interaction: |
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