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QuickView for Cefonicid (compound)


PubChem
Name: Cefonicid
PubChem Compound ID: 11006063
Description: A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Molecular formula: C18H18N6O8S3
Molecular weight: 542.569 g/mol
DrugBank
Identification
Name: Cefonicid
Name (isomeric): DB01328
Drug Type: small molecule
Description: A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Synonyms:
Cefonicidum [inn-latin]; Cefonicido [inn-spanish]
Brand: Monocid, Praticef
Category: Cephalosporins, Anti-Bacterial Agents, Antibacterial Agents
CAS number: 61270-58-4
Pharmacology
Indication: For the treatment of bacterial infections caused by susceptible microorganisms.
Pharmacology: Cefonicid is a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Mechanism of Action: Cefonicid, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
Protein binding: 98% bound to plasma proteins.
Biotransformation: Not metabolized.
Half Life: 4.5 hours
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
TobramycinIncreased risk of nephrotoxicity
ProbenecidProbenecid may increase the serum level of cefonicib.
AmikacinIncreased risk of nephrotoxicity
NetilmicinIncreased risk of nephrotoxicity
GentamicinIncreased risk of nephrotoxicity

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Carriers