Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Cefoperazone (compound)


PubChem
Name: Cefoperazone
PubChem Compound ID: 2630
Description: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
Molecular formula: C25H27N9O8S2
Molecular weight: 645.67 g/mol
Synonyms:
DivK1c_000128; KBio2_001919; KBio1_000128; KBioSS_001919; Spectrum3_000746; ChemDiv1_024737; Spectrum2_001764; Spectrum4_000322; KBio2_004487; KBio3_001552.
show more »
DrugBank
Identification
Name: Cefoperazone
Name (isomeric): DB01329
Drug Type: small molecule
Description: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.
Synonyms:
Cefoperazonum [inn-latin]; Cefoperazono [inn-spanish]
Brand: Cefobid
Category: Cephalosporins, Anti-Bacterial Agents, Antibacterial Agents
CAS number: 62893-19-0
Pharmacology
Indication: For the treatment of bacterial infections caused by susceptible microorganisms.
Pharmacology: Cefoperazone is a third generation cephalosporin antibiotic. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis
Mechanism of Action: Like all beta-lactam antibiotics, cefoperazone binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
Protein binding: The degree of reversible protein binding varies with the serum concentration from 93% at 25 mcg/mL to 90% at 250 mcg/mL and 82% at 500 mcg/mL. Cefotetan is 88% plasma protein bound.
Biotransformation: No significant quanitity of metabolites have been identified in urine.
Route of elimination: Cefoperazone is excreted mainly in the bile.
Half Life: The mean serum half-life is approximately 2.0 hours, independent of the route of administration.
Toxicity: Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Drug interaction:
TobramycinIncreased risk of nephrotoxicity
AmikacinIncreased risk of nephrotoxicity
NetilmicinIncreased risk of nephrotoxicity
GentamicinIncreased risk of nephrotoxicity

Targets


Transporters


Carriers