Name: | Cefoperazone |
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PubChem Compound ID: | 2630 |
Description: | Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections. |
Molecular formula: | C25H27N9O8S2 |
Molecular weight: | 645.67 g/mol |
Synonyms: |
DivK1c_000128; KBio2_001919; KBio1_000128; KBioSS_001919; Spectrum3_000746; ChemDiv1_024737; Spectrum2_001764; Spectrum4_000322; KBio2_004487; KBio3_001552.
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Name: | Cefoperazone |
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Name (isomeric): | DB01329 |
Drug Type: | small molecule |
Description: | Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections. |
Synonyms: |
Cefoperazonum [inn-latin]; Cefoperazono [inn-spanish]
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Brand: | Cefobid |
Category: | Cephalosporins, Anti-Bacterial Agents, Antibacterial Agents |
CAS number: | 62893-19-0 |
Indication: | For the treatment of bacterial infections caused by susceptible microorganisms. |
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Pharmacology: | Cefoperazone is a third generation cephalosporin antibiotic. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis |
Mechanism of Action: | Like all beta-lactam antibiotics, cefoperazone binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. |
Protein binding: | The degree of reversible protein binding varies with the serum concentration from 93% at 25 mcg/mL to 90% at 250 mcg/mL and 82% at 500 mcg/mL. Cefotetan is 88% plasma protein bound. |
Biotransformation: | No significant quanitity of metabolites have been identified in urine. |
Route of elimination: | Cefoperazone is excreted mainly in the bile. |
Half Life: | The mean serum half-life is approximately 2.0 hours, independent of the route of administration. |
Toxicity: | Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. |
Affected organisms: | Enteric bacteria and other eubacteria |
Drug interaction: |
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