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QuickView for Cefoxitin (compound)
PubChem
| Name: | Cefoxitin |
|---|---|
| PubChem Compound ID: | 2638 |
| Description: | A semisynthetic cephamycin antibiotic resistant to beta-lactamase. |
| Molecular formula: | C16H17N3O7S2 |
| Molecular weight: | 427.454 g/mol |
DrugBank
Identification
| Name: | Cefoxitin |
|---|---|
| Name (isomeric): | DB01331 |
| Drug Type: | small molecule |
| Description: | A semisynthetic cephamycin antibiotic resistant to beta-lactamase. |
| Brand: | Mefoxitin, Mefoxin |
| Category: | Cephalosporins, Anti-Bacterial Agents, Antibacterial Agents |
| CAS number: | 35607-66-0 |
Pharmacology
| Indication: | For the treatment of serious infections caused by susceptible strains microorganisms. |
|---|---|
| Pharmacology: |
Cefoxitin is a cephamycin antibiotic often grouped with the second-generation cephalosporins. It is active against a broad range of gram-negative bacteria including anaerobes. The methoxy group in the 7a position provides cefoxitin with a high degree of stability in the presence of beta-lactamases, both penicillinases and cephalosporinases, of gram...
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| Mechanism of Action: | The bactericidal action of cefoxitin results from inhibition of cell wall synthesis. |
| Biotransformation: | Minimal (approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6-hour period). |
| Route of elimination: | Approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6-hour period, resulting in high urinary concentrations. Cefoxitin passes into pleural and joint fluids and is detectable in antibacterial concentrations in bile. |
| Half Life: | The half-life after an intravenous dose is 41 to 59 minutes. |
| Toxicity: | The acute intravenous LD50 in the adult female mouse and rabbit was about 8.0 g/kg and greater than 1.0 g/kg, respectively. The acute intraperitoneal LD50 in the adult rat was greater than 10.0 g/kg. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
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Targets
Enzymes
