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QuickView for Ceftriaxone (compound)

Name: Ceftriaxone
PubChem Compound ID: 11614223
Description: A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
Molecular formula: C18H18N8Na2O8S3
Molecular weight: 616.562 g/mol
Name: Ceftriaxone
Name (isomeric): DB01212
Drug Type: small molecule
Description: A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
Ceftriazone; Cefatriaxone; Ceftriaxonum [INN-Latin]; Ceftriaxona [INN-Spanish]
Brand: Rocephine, Biotrakson
Category: Cephalosporins, Anti-Bacterial Agents
CAS number: 73384-59-5
Indication: For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Ceftriaxone is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Ceftriaxone has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ceftriaxone results from the inhibition ...
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Mechanism of Action:
Ceftriaxone works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Ceftriaxone binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these enzymes, Ceftriaxone results in th...
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Protein binding: 95%
Route of elimination: Thirty-three percent to 67% of a ceftriaxone dose was excreted in the urine as unchanged drug and the remainder was secreted in the bile and ultimately found in the feces as microbiologically inactive compounds.
Half Life: 5.8-8.7 hours
Clearance: 0.58 - 1.45 L/h [healthy adults receiving 0.15-3 g of CEFTRIAXONE]
Affected organisms: Enteric bacteria and other eubacteria
Drug interaction:
Calcium ChlorideCalcium Salts (Intravenous) may enhance the adverse/toxic effect of ceftriaxone. Ceftriaxone binds to calcium forming an insoluble precipitate. Concurrent or sequential use (within 48 hours) of ceftriaxone with calcium-containing solutions is contraindicated in neonates (28 days of age or younger). In other patients, these solutions can be used sequentially if the infusion lines are flushed with a compatible fluid between ceftriaxone and calcium-containing solution infusion.
AcenocoumarolThe cephalosporin, ceftriaxone, may increase the anticoagulant effect of acenocoumarol.
NeomycinIncreased risk of nephrotoxicity
KanamycinIncreased risk of nephrotoxicity
AmikacinIncreased risk of nephrotoxicity
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