Import Your Data

FAQ

More QuickView FAQs

QuickView

0
Meta-
Analysis

Bookmark Forward

QuickView for Cefuroxime (compound)

Summary
General Info

PubChem

PubChem Compound 2659

PubChem Compound 2659

Name:	Cefuroxime
PubChem Compound ID:	2659
Description:	Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
Molecular formula:	C₁₆H₁₆N₄O₈S
Molecular weight:	424.386 g/mol
Synonyms:	DivK1c_000159; Spectrum2_000706; KBio1_000159; KBio3_002603; KBio2_001903; Spectrum4_000156; Spectrum_001423; SPBio_000891; Spectrum3_001492; KBio2_007039. show more » DivK1c_000159; Spectrum2_000706; KBio1_000159; KBio3_002603; KBio2_001903; Spectrum4_000156; Spectrum_001423; SPBio_000891; Spectrum3_001492; KBio2_007039; KBioSS_001903; NINDS_000159; KBio2_004471; KBioGR_000632 show less «

DrugBank

Identification

Name:	Cefuroxime
Name (isomeric):	DB01112
Drug Type:	small molecule
Description:	Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.
Synonyms:	Cefuroxim; Cefuroximum [INN-Latin]; Cefuroxime [USAN:BAN:INN]; Cefuroximo [INN-Spanish]
Brand:	Kefzol, Velosef, Cefzil, Zinat, Rocephin, Zinnat, Duricef, Elobact, Mefoxin, Cephuroxime, Monocid, Cefotan, Ancef, Cefuril, Cefobid, Kerurox, Ceftin, Cedax, Maxipime, Cefizox, Mandol, Cefurax, Biofuroksym, Sharox, Zinacef, Cepazine, Kefurox, Oraxim
Category:	Cephalosporins, Anti-Bacterial Agents
CAS number:	55268-75-2

Pharmacology

Indication:	For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Pharmacology:	Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective ag... show more » Cefuroxime is a β-lactam type antibiotic. More specifically, it is a second-generation cephalosporin. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal. Cefuroxime is effective against the following organisms: Aerobic Gram-positive Microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Aerobic Gram-negative Microorganisms: Escherichia coli, Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (including beta-lactamase-producing strains), Neisseria gonorrhoeae (including beta-lactamase-producing strains). Spirochetes: Borrelia burgdorferi. Cefuroxime axetil is the prodrug show less «
Mechanism of Action:	Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxim... show more » Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor. show less «
Absorption:	Absorbed from the gastrointestinal tract. Absorption is greater when taken after food (absolute bioavailability increases from 37% to 52%).
Protein binding:	50% to serum protein
Biotransformation:	The axetil moiety is metabolized to acetaldehyde and acetic acid.
Half Life:	Approximately 80 minutes following intramuscular or intravenous injection.
Toxicity:	Allergic reactions might be expected, including rash, nasal congestion, cough, dry throat, eye irritation, or anaphylactic shock. Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.
Affected organisms:	Enteric bacteria and other eubacteria

Interactions

Food interaction:

Take with food to increase absorption.

Drug interaction:

Probenecid	Probenecid may increase the serum level of cefuroxime.
Tobramycin	Increased risk of nephrotoxicity
Amikacin	Increased risk of nephrotoxicity
Netilmicin	Increased risk of nephrotoxicity
Gentamicin	Increased risk of nephrotoxicity

Targets

Penicillin-binding proteins 1A/1B

Transporters

Oligopeptide transporter, small intestine isoform

Oligopeptide transporter, kidney isoform