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QuickView for Cephapirin (compound)
PubChem
| Name: | Cephapirin |
|---|---|
| PubChem Compound ID: | 2616 |
| Description: | Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms. |
| Molecular formula: | C17H17N3O6S2 |
| Molecular weight: | 423.466 g/mol |
| Synonyms: |
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[ (acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodium salt, (6R-trans)-; BL-P 1322; BLP sodium 1322; Sodium (6R, 7R)-3-hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido-5-thia-1- azabicyclo[4.2.0]oct-2-carboxylic acid, acetate ester; 24356-60-3; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodium salt, [6R-trans]-; CEPHAPIRIN - NSC 183501; Cefa lak; Sodium cephapirin; Sodium 7-(pyrid-4-ylthioacetamido)cephalosporanate.
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DrugBank
Identification
| Name: | Cephapirin |
|---|---|
| Name (isomeric): | DB01139 |
| Drug Type: | small molecule |
| Description: | Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms. |
| Synonyms: |
Cephapirin Sodium; Cefaprin sodium; Cefapirinum [INN-Latin]; Cephapirine; Cefaprin; Cefapirin; Cefapirina [INN-Spanish]; Cefapirine [INN-French]
|
| Brand: | Cefatrexyl, Cefadyl, Cefatrex, Ambrocef, Cefa |
| Category: | Cephalosporins, Anti-Bacterial Agents |
| CAS number: | 21593-23-7 |
Pharmacology
| Indication: | For treatment of infections caused by susceptible bacteria. |
|---|---|
| Pharmacology: | Cephapirin is a first-generation cephalosporin that has a wide spectrum of activity against gram-positive and gram-negative organisms. Cephapirin is more resistant to beta-lactamases than are the penicillins and so is effective against staphylococci, with the exception of methicillin-resistant staphylococci. |
| Mechanism of Action: | The bactericidal activity of cephapirin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). |
| Biotransformation: | Major metabolite detected is desacetylcephapirin. |
| Toxicity: | Rats exposed via the oral route to cephapirin displayed low acute toxicity (LD50 = 14000 mg/kg). The most common adverse reactions are hypersensitivity reactions and alterations to liver function. Evidence of white blood cell disorders and anaemia were noted in some subjects. |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
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Targets
