QuickView for Chlordiazepoxide (compound)

Methaminodiazepine hydrochloride; Libritabs hydrochloride; 7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine, 4-oxide, hydrochloride; Decacil; Tropium; Radepur; Eden; KBio1_000995; Contol; Napoton.
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Methaminodiazepine hydrochloride; Libritabs hydrochloride; 7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine, 4-oxide, hydrochloride; Decacil; Tropium; Radepur; Eden; KBio1_000995; Contol; Napoton; EINECS 200-371-0; Elenium; Ro 5-0690; Libritabs; CDO; Psicosan; Librelease; Balance (pharmaceutical); Helogaphen; Calmoden; ZINC00001118; Menrium; Risachief hydrochloride; Ifibrium; 7-Chloro-2-(methylamino)-5-phenyl-3H-1, 4-benzodiazepine-4-oxide hydrochloride; Napoton hydrochloride; 3H-1, 4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl-, 4-oxide, monohydrochloride; 438-41-5; Viopsicol; 3H-1,4-benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-,4-oxide; Mildmen; Zetran; Eden-psich; 7-Chloro-N-methyl-5-phenyl-3H-1,4-benzodiazepin-2-amine 4-oxide; 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl-, 4-oxide; HSDB 3028; 7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide; Chlordiazepoxidum [INN-Latin]; Methaminodiazepoxide; Chlordiazepoksid; Balance; 7-Chlor-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxid [German]; Chlorodiazepoxide; KBioGR_001016; Librium, hydrochloride; Clordiazepossido [Italian]; Risolid; Chlordiazepoxide monohydrochloride; Chloridiazepoxide hydrochloride; 7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine 4-oxide monohydrochloride; Chlordiazepoxide (JP15/USP); DEA No. 2744; component of Librax; Droxol hydrochloride; Librinin; Zeisin; SPBio_001113; 3H-1,4-Benzodiazepine, 7-chloro-2- (methylamino)-5-phenyl-, 4-oxide, monohydrochloride; Control; Spectrum4_000578; Chloridiazepide; Librium; 7-Cloro-2-metilamino-5-fenil-3H-1,4-benzodiazepina 4-ossido [Italian]; Libritabs (TN); Disarim; 58-25-3; Protensin; Silibrin; Chlordiazepoxide hydrochloride; 3H-1,4-Benzodiazepine, 7-chloro-2-(methylamino)-5-phenyl-, 4-oxide; Multum; NSC115748; DivK1c_000995; Chlorodiazepoxide hydrochloride; Chlordiazepoxydum; nchembio747-comp24; Mesural; SK-Lygen; Chlordiazepoxide; Chlordiazepoxide [USAN:BAN:INN:JAN]; D00267; Methaminodiazepoxide hydrochloride; Retcol; Chlozepid; Spectrum2_001157; Sonimen; Kalmocaps; Clordiazepoxido [INN-Spanish]; 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl, 4-oxide; Clopoxide chloride; NINDS_000995; Limbitrol
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Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence ...
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Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The drug seems to block EEG arousal from stimulation in the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
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Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor.BZDs, therefore, enhance GABA-mediate...
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Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor.BZDs, therefore, enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.
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