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QuickView for Chlorpheniramine (compound)
PubChem
| Name: | Chlorpheniramine |
|---|---|
| PubChem Compound ID: | 2725 |
| Description: | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE. |
| Molecular formula: | C16H19ClN2 |
| Molecular weight: | 274.788 g/mol |
| Synonyms: |
Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-; 2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N,N-dimethyl-; 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; NINDS_000596; Polaronil; C06905; 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine; 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-; Chlorprophenpyridamine; HSDB 3032.
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DrugBank
Identification
| Name: | Chlorpheniramine |
|---|---|
| Name (isomeric): | DB01114 |
| Drug Type: | small molecule |
| Description: | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE. |
| Synonyms: |
Chlorophenylpyridamine; Chlorprophenpyridamine; Dexchlorpheniramine Maleate; Clorfeniramina; Chlorpheniramine Maleate; Dexchlorpheniramine; Chlorphenamine; Chloropheniramine; Chlorophenylpyridamin; Chloroprophenpyridamine
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| Brand: | Chloropiril, Novo-Pheniram, Pyridamal 100, Chlo-Amine, Chlor-Tripolon, Chlor-Trimeton Repetabs, Kloromin, Polaramine, Allergican, Pediacare Allergy Formula, Cloropiril, Phenetron, Chlorate, Efidac 24 Chlorpheniramine Maleate, Telachlor, Polaronil, Antagonate, Histadur, Mylaramine, Teldrin, Chlor-Trimeton, Gen-Allerate, Piriton, Haynon, Aller-Chlor, Allergisan, Chlor-Trimeton Allergy |
| Brand name mixture: | Coricidin D Long Acting Tab(Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride), Corsym Suspension(Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride), Contact C Src(Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride), Alka Seltzer Plus Cold Medicine Evt(Acetylsalicylic Acid + Chlorpheniramine Maleate + Phenylpropan... show more » |
| Category: | Antihistamines, Histamine H1 Antagonists, Antipruritics, Anti-Allergic Agents |
| CAS number: | 132-22-9 |
Pharmacology
| Indication: | For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever. |
|---|---|
| Pharmacology: |
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once rel...
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| Mechanism of Action: | Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. |
| Absorption: | Well absorbed in the gastrointestinal tract. |
| Protein binding: | 72% |
| Biotransformation: | Primarily hepatic via Cytochrome P450 (CYP450) enzymes. |
| Half Life: | 21-27 hours |
| Toxicity: | LD50 = 306 mg/kg in humans, mild reproductive toxin to women of childbearing age. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
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