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QuickView for Chlorprothixene (compound)
PubChem
| Name: | Chlorprothixene |
|---|---|
| PubChem Compound ID: | 2729 |
| Description: | A thioxanthine with effects similar to the phenothiazine antipsychotics. |
| Molecular formula: | C18H18ClNS |
| Molecular weight: | 315.861 g/mol |
| Synonyms: |
NCIOpen2_008709; Spectrum2_000857; DivK1c_000143; NCIStruc2_001491; Prestwick1_000348; NCIOpen2_008749; NCIStruc1_001079; KBioGR_000998; Prestwick0_000348; NCI60_004376.
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DrugBank
Identification
| Name: | Chlorprothixene |
|---|---|
| Name (isomeric): | DB01239 |
| Drug Type: | small molecule |
| Description: | A thioxanthine with effects similar to the phenothiazine antipsychotics. |
| Synonyms: |
Chlothixen; Chlorprotixine; Chlorprothixen; Chlorprotixen; Cis-Chlorprothixene; CPT; Alpha-Chlorprothixene; Chlorprothixine; CPX; Chlorprotixene.
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| Brand: | Rentovet, Truxil, Taractan, Vetacalm, Truxaletten, Tardan, Trictal, Tactaran, Truxal, Paxyl, Iaractan, Tarasan, Traquilan |
| Category: | Dopamine Antagonists, Antipsychotic Agents, Antipsychotics |
| CAS number: | 113-59-7 |
Pharmacology
| Indication: | For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders. |
|---|---|
| Pharmacology: |
Chlorprothixene is a typical antipsychotic drug of the thioxanthine class. It has a low antipsychotic potency (half to 2/3 of chlorpromazine). An intrinsic antidepressant effect of chlorprothixene has been discussed, but not proven yet. Likewise, it is unclear, if chlorprothixene has genuine analgesic effects. An antiemetic effect, as with most ant...
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| Mechanism of Action: | Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. |
| Absorption: | Incomplete bioavailability. |
| Biotransformation: | Hepatic |
| Half Life: | 8 to 12 hours |
| Toxicity: | Symptoms of overdose include difficulty in breathing (severe), dizziness (severe), drowsiness (severe), muscle trembling, jerking, stiffness, or uncontrolled movements (severe), small pupils, unusual excitement, and unusual tiredness or weakness (severe). |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
Transporters
