Name: | Chlorzoxazone |
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PubChem Compound ID: | 11052057 |
Description: | A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) |
Molecular formula: | C7H4ClNO2 |
Molecular weight: | 168.566 g/mol |
Name: | Chlorzoxazone |
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Name (isomeric): | DB00356 |
Drug Type: | small molecule |
Description: | A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) |
Synonyms: |
Chlorzoxane; Chloroxazone; Chlorzoxazon
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Brand: | Mioran, Neoflex, Remular, Flexazone, Solaxin, EZE-DS, Escoflex, Pathorysin, Paraflex, Strifon Forte Dsc, Parafon Forte Dsc, Relaxazone, Usaf Ma-10, Remular-S, Biomioran, Myoflexin, Miotran, Myoflexine |
Brand name mixture: | Acetazone Forte(Acetaminophen + Chlorzoxazone), Gin Pain Pills- Chlorzoxazone & Acetamin.Tab(Acetaminophen + Chlorzoxazone), Back-Aid Forte - Tab(Acetaminophen + Chlorzoxazone), Acetazone Forte C8(Acetaminophen + Chlorzoxazone + Codeine Phosphate), Parafon Forte C8 W Codeine Tab(Acetaminophen + Chlorzoxazone + Codeine Phosphate), Gin Pain Pills ... show more » |
Category: | Muscle Relaxants, Central |
CAS number: | 95-25-0 |
Indication: | For the relief of discomfort associated with acute painful musculoskeletal conditions. |
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Pharmacology: |
Chlorzoxazone, a synthetic compound, inhibits antigen-induced bronchospasms and, hence, is used to treat asthma and allergic rhinitis. Chlorzoxazone is used as an ophthalmic solution to treat conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis. Chlorzoxazone is also a centrally-acting agent for painful musculosk...
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Mechanism of Action: |
Chlorzoxazone inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Chlorzoxazone also may reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium and potassium influx which would lead to ...
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Protein binding: | 13-18% |
Biotransformation: | Chlorzoxazone is rapidly metabolized in the liver and is excreted in the urine, primarily in a conjugated form as the glucuronide. |
Route of elimination: | Chlorzoxazone is rapidly metabolized and is excreted in the urine, primarily in a conjugated form as the glucuronide. |
Toxicity: | Oral, mouse: LD50 = 440 mg/kg; Oral, rat: LD50 = 763 mg/kg; Symptoms of overdose include diarrhea, dizziness, drowsiness, headache, light-headedness, nausea, and vomiting. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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