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QuickView for Cilazapril (compound)

Summary
General Info

PubChem

PubChem Compound 2751

PubChem Compound 2751

Name:	Cilazapril
PubChem Compound ID:	2751
Description:	One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.
Molecular formula:	C₂₂H₃₁N₃O₅
Molecular weight:	417.499 g/mol

DrugBank

Identification

Name:	Cilazapril
Name (isomeric):	DB01340
Drug Type:	small molecule
Description:	One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.
Synonyms:	Inhibace
Category:	Angiotensin-converting Enzyme Inhibitors, Antihypertensive Agents
CAS number:	92077-78-6

Pharmacology

Indication:	Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure.
Pharmacology:	Cilazapril inhibits the production angiotensin II. By doing so, it decreases sodium and water reabsorption (via aldosterone) and it decreases vasoconstriction. The combined effect of this is a decrease in vascular resistance, and therefore, blood pressure.
Mechanism of Action:	Cilazapril is a pyridazine ACE inhibitor. It competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II levels results in a decrease in blood pressure, an inc... show more » Cilazapril is a pyridazine ACE inhibitor. It competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II levels results in a decrease in blood pressure, an increase in renin activity, and stimulation of baroreceptor reflex mechanisms. Kininase II, an enzyme which degrades the vasodilator bradykinin, is identical to ACE and may also be inhibited. show less «

Interactions

Food interaction:

Food decreases cilazapril absorption with no significant clinical impact.

Take without regard to meals.

Drug interaction:

Lithium	The ACE inhibitor increases serum levels of lithium
Tizanidine	Tizanidine increases the risk of hypotension with the ACE inhibitor
Spironolactone	Increased risk of hyperkalemia
Potassium	Increased risk of hyperkalemia
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.

Targets

Angiotensin-converting enzyme

Transporters

Multidrug resistance protein 1

Oligopeptide transporter, small intestine isoform

Oligopeptide transporter, kidney isoform