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QuickView for Cinitapride (compound)

Name: cinitapride
PubChem Compound ID: 6446850
Molecular formula: C25H34N4O8
Molecular weight: 518.56 g/mol
LAS 17177; Benzamide, 4-amino-N-(1-(3-cyclohexen-1-ylmethyl)-4-piperidinyl)-2-ethoxy-5-nitro-, (E)-2-butenedioate (1:1); Cidine; 67135-13-1; Cinitapride hydrogen tartrate
Name: cinitapride
Name (isomeric): DB08810
Drug Type: small molecule
Brand: Pemix, Cinmove, Paxapride, Cintapro, Cidine, Blaston
Category: Antiemetics
CAS number: 66564-14-5
Indication: For the treatment of gastrointestinal disorders associated with motility disturbances such as gastroesophageal reflux disease, non-ulcer dyspepsia and delayed gastric emptying.
Mechanism of Action: Cinitapride is a substituted benzamide with 5-HT receptor antagonist and agonist activity.
Absorption: The absorption of cinitapride (12mg) following oral administration was rapid, with peak levels being achieved 2 h after dosing; absorption following intramuscular administration (4mg) was even more rapid, with peak levels (50% more that oral levels) being achieved 1 h after dosing.
Half Life: 3-5 h during the first 8 h and a residual half-life greater than 15 h thereafter.
Toxicity: The symptoms of overdose include drowsiness, confusion and extrapyramidal effects.
Affected organisms: Humans and other mammals
Drug interaction:
ScopolamineAnticholinergic agents like scopolamine may reduce the action of cinitapride.
Digoxin Immune FabCinitapride can alter the absorption of digoxin as it simulates gastric emptying.
AtropineAnticholinergic agents like atropine may reduce the action of cinitapride.
DigoxinCinitapride can alter the absorption of digoxin as it simulates gastric emptying.
MethylscopolamineAnticholinergic agents like methylscopolamine may reduce the action of cinitapride.