Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Ciprofloxacin (compound)

Name: Ciprofloxacin
PubChem Compound ID: 10336735
Description: A broad-spectrum antimicrobial carboxyfluoroquinoline.
Molecular formula: C17H18FN3O3
Molecular weight: 330.344 g/mol
Name: Ciprofloxacin
Name (isomeric): DB00537
Drug Type: small molecule
Description: A broad-spectrum antimicrobial carboxyfluoroquinoline.
Ciprofloxacin monohydrochloride; Ciprofloxacina; Ciprofloxacin dihydrochloride; Ciprofloxacin hydrochloride; Ciprofloxacin HCl
Brand: Velomonit, Ciflox, Ciprinol, Ciprobay, Ciproxan, Ciproquinol, Bacquinor, Cipro XL, Bernoflox, Flociprin, Ciloxan, Septicide, Cipromycin, Cifloxin, Cipro, Ciprodar, Ciprocinol, Proquin XR, Cipro I.V., Cipro XR, Ocuflox, Baycip, Ciproxin, Floxin
Brand name mixture: Cipro HC Otic Suspension(Ciprofloxacin hydrochloride + Hydrocortisone), Ciprodex(Ciprofloxacin hydrochloride + Dexamethasone)
Category: Anti-Infective Agents, Quinolones, Nucleic Acid Synthesis Inhibitors, Anti-Infectives
CAS number: 85721-33-1
Indication: For the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).
Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, ...
show more »
Mechanism of Action: The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination.
Absorption: Rapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.
Protein binding: 20 to 40%
Biotransformation: Hepatic. Four metabolites have been identified in human urine which together account for approximately 15% of an oral dose. The metabolites have antimicrobial activity, but are less active than unchanged ciprofloxacin.
Route of elimination: Approximately 40 to 50% of an orally administered dose is excreted in the urine as unchanged drug.
Half Life: 4 hours
Clearance: Renal cl=300 mL/min
Toxicity: The major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics.
Affected organisms: Enteric bacteria and other eubacteria
Food interaction:
Avoid milk, calcium containing dairy products, iron, magnesium, zinc, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
Take without regard to meals.
Take with a full glass of water.
Avoid excessive quantities of coffee or tea (Caffeine).
Drug interaction:
MethotrexateCiprofloxacine may decrease the metabolism of methotrexate. Monitor for changes adverse effects of methotrexate if ciprofloxacin is initiated.
OxtriphyllineCiprofloxacin may increase the effect of oxtriphylline.
IronFormation of non-absorbable complexes
DihydroxyaluminiumFormation of non-absorbable complexes
EthotoinDecreases the hydantoin effect
show more »