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QuickView for Clobazam (compound)
PubChem
| Name: | clobazam |
|---|---|
| PubChem Compound ID: | 2789 |
| Molecular formula: | C16H13ClN2O2 |
| Molecular weight: | 300.739 g/mol |
| Synonyms: |
EINECS 244-908-7; BRN 0758410; Mystan (TN); nchembio747-comp39; H-4723; 1-Phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1, 5-benzodiazepine; Clobazam [USAN:BAN:INN]; Urbanyl; Clobazam; Clobazamum [INN-Latin].
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DrugBank
Identification
| Name: | clobazam |
|---|---|
| Name (isomeric): | DB00349 |
| Drug Type: | small molecule |
| Brand: | Urbadan, Chlorepin, Frisium, Mystan, Urbanyl, Clorepin |
| Category: | Benzodiazepines, Anticonvulsants |
| CAS number: | 22316-47-8 |
Pharmacology
| Indication: | For treatment and management of epilepsy and anxiety disorder. |
|---|---|
| Pharmacology: | Clobazam is a barbiturate used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. |
| Mechanism of Action: | Clobazam binds at a distinct binding site associated with a Cl- ionopore at the GABA-A receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is prolonged as a result. |
| Absorption: | Bioavailability is 90%. |
| Protein binding: | 83% |
| Biotransformation: | Hepatic. Clobazam has two major metabolites: N-desmethyl-clobazam and 4'-hydroxyclobazam, the former of which is active. The demethylation is facilitated by CYP2C19, CYP3A4, and CYP2B6 and the 4'-hydroxyclobazam by CYP2C18 and CYP2C19. |
| Half Life: | 18 hours |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
Enzymes
