Name: | clocortolone |
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PubChem Compound ID: | 11648130 |
Molecular formula: | C24H30ClFO5 |
Molecular weight: | 452.943 g/mol |
Name: | clocortolone |
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Name (isomeric): | DB00838 |
Drug Type: | small molecule |
Synonyms: |
Clocortolone pivalate
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Brand: | Cloderm |
Category: | Corticosteroids, topical |
CAS number: | 34097-16-0 |
Indication: | For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp. |
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Pharmacology: |
Like other topical corticosteroids, clocortolone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Clocortolone is a moderate potency topical corticosteroid that should not be...
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Mechanism of Action: |
The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the bio...
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Absorption: | Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption. |
Biotransformation: | Metabolized, primarily in the liver, and then excreted by the kidneys. |
Toxicity: | Topically applied clocortolone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress). |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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