Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Cortisone acetate (compound)

Name: cortisone acetate
PubChem Compound ID: 10024054
Molecular formula: C23H30O6
Molecular weight: 402.481 g/mol
Name: cortisone acetate
Name (isomeric): DB01380
Drug Type: small molecule
Category: Corticosteroid, Anti-inflammatory Agents
CAS number: 50-04-4
Indication: For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders.
As a glucocorticoid agent, cortisone acetate changes genetic transcription levels causing varied metabolic effects and a modified immune response to varied stimuli. lucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of wh...
show more »
Mechanism of Action:
Cortisone acetate binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription fact...
show more »
Route of elimination: Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.
Toxicity: Side effects include inhibition of bone formation, suppression of calcium absorption, delayed wound healing and hyperglycemia.
Affected organisms: Humans and other mammals
Drug interaction:
RifampinThe enzyme inducer, rifampin, may decrease the effect of the corticosteroid, cortisone acetate.
VecuroniumVecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Cortisone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
TrastuzumabTrastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
PyridostigmineThe corticosteroid, cortisone acetate, may decrease the effect of the anticholinesterase, pyridostigmine.
PhenytoinThe enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, cortisone acetate.
show more »